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Structural changes in nucleoprotein systems under the influence of blood sera of healthy and sick persons

  • Biochemistry and Biophysics
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Interaction between model DNP systems of chromatin and blood sera of healthy and sick persons was investigated by a thermomechanical method. Healthy human blood serum was shown to cause decondensation of DNP systems. The intensity of this action varied when pathological sera with modified composition were used: The sera of patients with systemic lupus erythematosus increased the degree of condensation, whereas sera from patients with schizophrenia increased the decondensation of the DNP systems compared with healthy sera. The action of the sera was unconnected with activity of the serum enzymes. The role of serum components in the regulation of the structural and functional properties of chromatin is discussed.

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Literature Cited

  1. P. D. Bonartsev, Zh. Nevropatol. Psikhiatr., No. 6, 878 (1973).

    Google Scholar 

  2. E. V. Gubler and A. A. Genkin, The Use of Nonparametric Criteria of Statistics in Medical and Biological Research [in Russian], Leningrad (1973).

  3. R. R. Lideman and L. L. Prilipko, Dokl. Akad. Nauk SSSR,192, 938 (1970).

    Google Scholar 

  4. D. V. Lozovskii, “Special biological features of the blood serum of patients with schizophrenia,” Doctoral Dissertation, Moscow (1970).

  5. V. A. Nasonova, Systemic Lupus Erythematosus [in Russian], Moscow (1972).

  6. D. M. Spitkovskii, V. T. Andrianov, et al., Radiation Biophysics of Nucleoproteins [in Russian], Moscow (1969).

  7. D. M. Spitkovskii, Vest. Akad. Med. Nauk SSSR, No. 1, 29 (1973).

    Google Scholar 

  8. K. N. Fedorova and V. M. Inshakova, Byull. Éksp. Biol. Med., No. 10, 97 (1974).

    Google Scholar 

  9. R. B. Khesin and B. A. Leibovich, Molekul. Biol. No. 10, 3 (1976).

    Google Scholar 

  10. W. H. Brooks and M. G. Netsky, J. Exp. Med.,136, 6131 (1972).

    Google Scholar 

  11. R. Dulbecco, Nature,227, 798 (1970).

    Google Scholar 

  12. G. S. Liacco and P. S. Manconi, Folia Allergol. (Rome),21, 71 (1974).

    Google Scholar 

  13. F. L. Moolthen and N. L. Bucher, Science,158, 272 (1967).

    Google Scholar 

  14. Z. C. Omodei and A. Neri, Lancet,1, 745 (1974).

    Google Scholar 

  15. H. M. Temin and R. W. Pierson, in: Growth, Nutrition, and Metabolism of Cells in Culture (ed. by G. H. Rothblat and V. J. Christofalo), Academic Press, Vol. 1, New York (1972), p. 50.

    Google Scholar 

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Authors
  1. V. M. Inshakova
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  2. M. I. Faktor
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  3. D. M. Spitkovskii
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Inshakova, V.M., Faktor, M.I. & Spitkovskii, D.M. Structural changes in nucleoprotein systems under the influence of blood sera of healthy and sick persons. Bull Exp Biol Med 82, 1670–1673 (1976). https://doi.org/10.1007/BF00790381

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  • DOI: https://doi.org/10.1007/BF00790381

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