Abstract
A study of changes in the ECoG and ECG recorded during combined action ofClostridium perfringens type A toxin and filtrate of a broth culture ofClostridium butyricum showed that desynchronization and subsequent depression of cortical electrical activity developed later than after exposure toCl. perfringens toxin alone. The general character of the changes in the cortical rhythm under these circumstances remained the same as after administration ofCl. perfringens toxin alone. ECG changes arose after shorter intervals. TheCl. butyricum filtrate caused changes in neither the ECoG nor the ECG. It is postulated that the effect of metabolic products ofCl. butyricum is to increase the permeability of the tissue barriers and, consequently, to promote penetration ofCl. perfringens toxin into the tissues, including into the CNS.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
D. A. Arapov, Anaerobic Gas Infection [in Russian], Moscow (1972).
A. N. Berkutov, “Anaerobic infection of gunshot wounds,” Doctoral Dissertation, Leningrad (1951).
I. M. Velikanov, Sov. Khir.,3, No. 1–2, (1932).
N. N. Grashchenkov, P. P. Sakharov, and E. I. Gudkova, Zh. Mikrobiol., No. 7–8, 4 (1945).
Yu. I. Donets, Zh. Mikrobiol., No. 3, 108 (1962).
S. P. Zhak, Zh. Mikrobiol., No. 6, 73 (1957).
O. A. Kirilenko, “Potentiation of the action of tetanus toxin by metabolic products ofStaphylococcus, Escherichia coli, andProteus,” Doctoral Dissertation, Odessa (1966).
O. A. Kirilenko, S. M. Minervin, and L. Ya. Rozanov, Zh. Mikrobiol., No. 10, 105 (1965).
A. N. L'vov, Gas Gangrene [in Russian], Moscow (1946).
K. I. Matveev and Yu. B. Volgin, in: Textbook of Microbiology and the Clinical Aspects and Epidemiology of Infectious Diseases in Several Volumes [in Russian], Vol. 7, Moscow (1966), pp. 565–634.
S. M. Minervin, Abstracts of Proceedings of the 13th All-Union Congress of Hygienists, Epidemiologists, Microbiologists, and Specialists in Infectious Diseases [in Russian], Vol. 2, Moscow (1956), pp. 60–61.
A. I. Mitskevich, “Clinical and experimental data on the pathogenesis, diagnosis, and treatment of gas gangrene” [in Russian], Doctoral Dissertation, Odessa (1970).
V. R. Savin, Mikrobiol. Zh., No. 4, 51 (1960).
A. V. Tselukh, Mikrobiol. Zh., No. 2, 129 (1967).
A. V. Tselukh, Abstracts of Proceedings of the 9th Ukrainian Republican Congress of Epidemiologists, Microbiologists, and Specialists in Infectious Diseases [in Russian], Kiev and Dnepropetrovsk (1975), pp. 409–411.
A. V. Tselukh, R. F. Makul'kin, and G. N. Kryzhanovskii, Byull. Éksp. Biol. Med., No. 10, 1192 (1976).
J. D. MacLennan, Bact. Rev.,26, 177 (1962).
J. Zeissler et al., Die Gasödeme des Menschen, Darmstadt (1958).
Author information
Authors and Affiliations
Additional information
Departments of Microbiology and Pathological Physiology, N. I. Pirogov Odessa Medical Institute. Laboratory of General Pathology of the Nervous System, Institute of General Pathology and Pathological Physiology, Academy of Medical Sciences of the USSR, Moscow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 82, No. 11, pp. 1305–1310, November, 1976.
Rights and permissions
About this article
Cite this article
Tselukh, A.V., Makul'kin, R.F. & Kryzhanovskii, G.N. Changes in cortical electrical activity following combined action ofClostridium perfringens toxin and metabolic products ofClostridium butyricum . Bull Exp Biol Med 82, 1629–1634 (1976). https://doi.org/10.1007/BF00790368
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00790368