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Effect of chronic stimulation of negative and positive emotiogenic hypothalamic centers on production of cardiac arrhythmias

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Changes in cardiac activity arising during prolonged (up to 1 or 2 weeks) electrical stimulation of the ventromedial hypothalamic nuclei were investigated in chronic experiments on 46 rabbits. Disturbances of the cardiac rhythm, in the form of tachycardia, atrial flutter and fibrillation, ventricular extrasystoles, and paroxysmal ventricular techysystole developed mainly during the first days of stimulation and were stopped by administration of Inderal. In animals subjected to stimulation of the ventromedial nuclei for 1–2 weeks, functional “weakness” of the cardiac pacemakers was found, as shown by an increase in poststimulation depression of automatic activity of the pacemakers and the appearance of Luciani's periods. Disturbances of the cardiac rhythm arising in response to stimulation of the ventromedial nuclei are abolished by stimulation of the lateral hypothalamic area.

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Authors
  1. L. S. Ul'yaninskii
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  2. A. N. Balashov
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  3. A. V. Gritsak
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  4. S. I. Kashtanov
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Ul'yaninskii, L.S., Balashov, A.N., Gritsak, A.V. et al. Effect of chronic stimulation of negative and positive emotiogenic hypothalamic centers on production of cardiac arrhythmias. Bull Exp Biol Med 82, 1605–1608 (1976). https://doi.org/10.1007/BF00790361

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  • DOI: https://doi.org/10.1007/BF00790361

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