Abstract
The dynamics of the pulmonary ventilation, electrical activity of the intercostal muscles, and composition of the alveolar gas were investigated in 12 healthy men performing measured muscular work and breathing mixtures of different composition. The respiratory response in the initial period of work during inhalation of a hypoxic, hypercapnic gas mixture was greater than when breathing air, but after hyperventilation with oxygen it virtually disappeared. The fast component of the ventilatory response to muscular work is evidently due largely to increased sensitivity of the respiratory center to impulses from chemoreceptors.
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Breslav, I.S., Isaev, G.G. & Shmeleva, A.M. Mechanism of the fast neurogenic component of the respiratory response to muscular work. Bull Exp Biol Med 82, 1597–1599 (1976). https://doi.org/10.1007/BF00790358
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DOI: https://doi.org/10.1007/BF00790358