Bulletin of Experimental Biology and Medicine

, Volume 82, Issue 1, pp 1081–1084 | Cite as

Effect of cortisone on posttraumatic regeneration of mammalian skeletal muscles

  • T. M. Kovalenko
Experimental Biology


Prolonged administration of cortisone to sexually immature rabbits and rats after previous injury to the tibialis anterior muscle inherits the regeneration of skeletal muscle tissue, as manifested by delay in growth of the myosymplasts and muscle tubes. In rabbits by the 15th day after the operation the area of the muscular components of the regenerating focus was less than their area in the control. Analysis of the intensity of methionine-3H incorporation into the regenerating elements of the muscle tissue showed a significant decrease in uptake of the label into nuclear and cytoplasmic proteins of the myosymplasts of rats receiving cortisone. Inhibition of protein synthesis in the early stage of differentiation of muscle tissue was less marked than in mature differentiated muscle fibers of the intact muscle.

Key Words

Regeneration of skeletal muscles incorporation of methionine-3area of components of regenerating focus 


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Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • T. M. Kovalenko
    • 1
  1. 1.Department of BiologyI. P. Pavlov First Leningrad Medical InstituteUSSR

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