Bulletin of Experimental Biology and Medicine

, Volume 82, Issue 1, pp 1069–1072 | Cite as

Effect of injury to the microvessels on the frequency of tumor cell lodgment in them

  • A. M. Chernukh
  • V. S. Shinkarenko


The action of local laser injury to the microvessels on the frequency of lodgment of tumor cells and on the ability of the cells to migrate from the lumen of the vessel was studied. A television microscope with video tape recorder and UV-laser were used. Cells of a Zajdela's ascites hepatoma were injected into the blood stream of a rat. Lodgment of tumor cells in the mesenteric vessels was observed infrequently (11%). The lodged cells adhered to the vessel wall and migrated from its lumen. Injury to the vessel wall by the laser beam led to the formation of microthrombi and to an increase in the frequency of lodging of the tumor cells in the vessels: 82% instead of 11%. The frequency of migration of cells from the lumen of the vessel under these circumstances, however, was reduced. The results confirm the role of microthrombus formation in metastasization; however, the role of microthrombus formation mav be exerted in different directions for although the frequency of adhesion of the tumor cells is increased, their mobility is reduced for a few a few hours after lodging in the microvessels.

Key Words

tumor cells metastasization microvessels laser 


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Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • A. M. Chernukh
    • 1
  • V. S. Shinkarenko
    • 1
  1. 1.Laboratory of General Pathology and Experimental Therapy, Institute of General Pathology and Pathological PhysiologyAcademy of Medical Sciences of the USSRMoscow

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