Abstract
Investigation of an unusual antigen containing the carcinogenic tryptophan metabolite 3-hydroxyanthranilic acid as hapten (3-HAA-antigen) showed that it is present in the blood serum of most patients with malignant tumors in different situations and in different stages of the disease. The 3-HAA-antigen was found only rarely in patients with noncancerous diseases and was not found in the blood of healthy donors or of patients with benign tumors. The importance of the results for the diagnosis of cancer irrespective of its situation is discussed.
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Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 82, No. 7, pp. 850–852, July, 1976.
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Korosteleva, T.A., Klyucharev, B.V., Mel'nikov, R.A. et al. Discovery of an antigen containing 3-hydroxyanthranilic acid in the blood serum of patients with tumors in various situations. Bull Exp Biol Med 82, 1057–1059 (1976). https://doi.org/10.1007/BF00789870
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DOI: https://doi.org/10.1007/BF00789870