Adrenocortical function during traumatic shock in rats after removal or deafferentation of the hypothalamus
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The 11-hydroxycorticosteroid (11-HCS) concentration was determined in the blood plasma of rats undergoing a mock operation, and rats with an intact, extirpated, or deafferented medio-basal hypothalamus (MBH), during traumatic shock. No significant differences were found in the basal 11-HCS level in the rats of the different groups. Removal of MBH led to a decrease in weight of the adrenal and pituitary glands, whereas deafferentation of MBH led to an increase in weight of the adrenals. The 11-HCS level in rats with complete deafferentation of MBH was significantly higher than in the animals undergoing the mock operation when both were in a state of traumatic shock.
Key Wordscorticosterone shock hypothalamus
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