Adrenocortical function during traumatic shock in rats after removal or deafferentation of the hypothalamus

  • G. S. Mazurkevich
  • N. A. Kulikova
Pathological Physiology and General Pathology
  • 7 Downloads

Abstract

The 11-hydroxycorticosteroid (11-HCS) concentration was determined in the blood plasma of rats undergoing a mock operation, and rats with an intact, extirpated, or deafferented medio-basal hypothalamus (MBH), during traumatic shock. No significant differences were found in the basal 11-HCS level in the rats of the different groups. Removal of MBH led to a decrease in weight of the adrenal and pituitary glands, whereas deafferentation of MBH led to an increase in weight of the adrenals. The 11-HCS level in rats with complete deafferentation of MBH was significantly higher than in the animals undergoing the mock operation when both were in a state of traumatic shock.

Key Words

corticosterone shock hypothalamus 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    I. G. Akmaev, Z. A. Kabolova, A. P. Popov, et al., Probl. Éndokrinol., No. 6, 62 (1973).Google Scholar
  2. 2.
    L. N. Maslova, Pat. Fiziol., No. 1, 43 (1974).Google Scholar
  3. 3.
    E. V. Naumenko, L. N. Maslova, L. A. Koryakina, et al., Probl. Éndokrinol., No. 5, 72 (1972).Google Scholar
  4. 4.
    Yu. A. Pankov and I. Ya. Usvatova, Publications on New Apparatus and Methods of the First Moscow Medical Institute [in Russian], Vol. 3, Moscow (1965), pp. 137–145.Google Scholar
  5. 5.
    J. Dunn and V. Critchlow, Proc. Soc. Exp. Biol. (New York).142, 749 (1973).Google Scholar
  6. 6.
    M. Goth, C. Nyakas, and E. Endroczi, Endokrinologie,61, 265 (1973).Google Scholar
  7. 7.
    M. A. Greer, C. F. Allen, F. P. Gibbs, et al., Endocrinology,86, 1404 (1970).Google Scholar
  8. 8.
    B. Halász and L. Pupp, Endocrinology,77, 553 (1965).Google Scholar
  9. 9.
    G. B. Makara, E. Stark, and M. Palkovits, J. Endocrinol.,47, 411 (1970).Google Scholar
  10. 10.
    I. Vermes, D. Molnár, and G. Telegdy, Acta Physiol. Acad. Sci. Hung.,43, 239 (1973).Google Scholar

Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • G. S. Mazurkevich
    • 1
  • N. A. Kulikova
    • 1
  1. 1.Laboratory of Pathologicay PhysiologyI. I. Dzhanelidze Emergency Aid Research InstituteLeningrad

Personalised recommendations