Abstract
The effect of pharmacological blockade and stimulation of the adrenergic innervation on the toxicity and cumulative effect of strophanthin was studied in experiments on cats. Premedication with propranolol and preliminary reserpinization were found to increase tolerance to strophanthin and to weaken its cumulative effect. Isoprenaline sharply increased sensitivity to the cardiac glycoside, but in this case cumulation was totally absent.
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Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 80, No. 8, pp. 69–71, August, 1975.
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Gendenshtein, É.I., Volkova, N.D. Effect of some adrenergic agents on the cumulative effect of strophanthin. Bull Exp Biol Med 80, 934–936 (1975). https://doi.org/10.1007/BF00789274
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DOI: https://doi.org/10.1007/BF00789274