Skip to main content
SpringerLink
Log in

Effect of trifluoperazine on transmission of excitation in the rabbit brain during its prolonged administration

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Cortical unit responses to electrical stimulation of neighboring areas were studied in experiments on waking rabbits treated with trifluoperazine in a dose of 1 mg/kg daily for 2 weeks. Measurement of dispersion of poststimulus histograms showed a decrease in the magnitude and duration of cortical unit responses after stimulation under the influence of trifluoperazine. The effect of trifluoperazine is examined from the point of view of impairment of impulse conduction in neuron nets.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature Cited

  1. G. Ya. Avrutskii, “General principles of psychopharmacotherapy,” in: Psychotropic Drugs in Medical Practice [in Russian], Meditsina, Moscow (1971), pp. 9–21.

    Google Scholar 

  2. I. I. Glezer and I. S. Yakobson, “Histochemical and electron-microscopic data on the action of trifluoperazine on the albino rat brain,” Zh. Nevropat. i Psikhiat., No. 4, 576 (1967).

    Google Scholar 

  3. V. V. Zakusov, Pharmacology of Central Synapses [in Russian], Meditsina, Moscow (1973).

    Google Scholar 

  4. G. R. Dubinskaya, “Ultrastructure of the cerebral cortex during the action of trifluoperazine,” in: Modern Psychotropic Drugs [in Russian], No. 3, Moscow, pp. 108–114.

  5. L. G. Magazanik, “Effect of some membrane stabilizers on function of the neuromuscular synapse,” Fiziol. Zh. SSSR, No. 9, 1313 (1971).

    Google Scholar 

  6. A. V. Nemtsov, “Action of chlorpromazine and trifluoperazine on cortical unit discharges of rabbits during chronic administration of the drugs,” Zh. Vyssh. Nerv. Deyat., No. 1, 199 (1974).

    Google Scholar 

  7. S. A. Sarkisov, M. N. Belaya, and G. N. Krivitskaya, “Morpho-functional and biochemical changes in various brain formations under the influence of trifluoperazine,” Zh. Nevropat. i Psikhiat., No. 8, 1169 (1966).

    Google Scholar 

  8. J. C. Eccles, The Physiology of Nerve Cells, Johns Hopkins Press, Baltimore (1957).

    Google Scholar 

  9. W. R. Adey, N. A. Buchwald, and D. Lindsley, “Amygdaloid, pallidal, and peripheral influences on mesencephalic unit firing patterns with reference to mechanisms of tremor,” Electroenceph. Clin. Neurophysiol.,12, 21 (1960).

    PubMed  Google Scholar 

  10. G. Cassano, S. Sjöstrand, and E. Hansson, “Distribution of S35-chlorpromazine in cat brain,” Arch. Internat. Pharmacodyn.,156, 48 (1965).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Psychopharmacology, Moscow Research Institute of Psychiatry, Ministry of Health of the RSFSR, USSR

    A. V. Nemtsov & K. A. Rad'ko

Authors
  1. A. V. Nemtsov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. A. Rad'ko
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 80, No. 8, pp. 63–66, August, 1975.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nemtsov, A.V., Rad'ko, K.A. Effect of trifluoperazine on transmission of excitation in the rabbit brain during its prolonged administration. Bull Exp Biol Med 80, 926–929 (1975). https://doi.org/10.1007/BF00789272

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00789272

Key Words

Search

Navigation