Advertisement

Bulletin of Experimental Biology and Medicine

, Volume 80, Issue 2, pp 923–925 | Cite as

Effect of psychotropic drugs on conditioned reflexes in cats after emotional excitation

  • R. M. Salimov
Pharmacology
  • 13 Downloads

Abstract

After emotional responses of fear and rage differential inhibition and shortterm memory are disturbed in cats. Trifluoperazine, haloperidol, amitriptyline, imipramine, chlordiazepoxide, diazepam, and benactyzine prevent the development of these disturbances. Chlorpromazine, as well as trifluoperazine and haloperidol in large doses (1 and 2 mg/kg), intensify the disturbances taking place. Unlike neuroleptics, the tranquilizers and antidepressants tested restore normal higher nervous activity over a wider range of doses; consequently, their use is to be preferred for the elimination of adverse sequelae of powerful emotional responses.

Key words

emotional stress conditioned reflex psychotropic drugs 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    V. A. Andreeva, “Interaction between differential and extinctive inhibition against the background of limiting inhibition,” Zh. Vyssh. Nerv. Deyat., No. 4, 643 (1966).Google Scholar
  2. 2.
    Yu. V. Burov, “Changes in the electroencephalogram during orienting and conditioned-defensive reflexes under the influence of tranquilizers,” Farmakol. i Toksikol., No. 4, 389 (1965).Google Scholar
  3. 3.
    Yu. V. Burov and R. M. Salimov, “Effect of pharmacological agents on the sequelae of emotional excitation in cats,” Zh. Vyssh. Nerv. Deyat., No. 4, 825 (1974).Google Scholar
  4. 4.
    Sh. L. Dzhalagoniya, “Reproduction of a neurotic state in monkeys with an intact brain and after injury to the frontal lobes,” Zh. Vyssh. Nerv. Deyat., No. 4, 708 (1972).Google Scholar
  5. 5.
    Sh. L. Dzhalagoniya, “Characteristics of higher nervous activity of monkeys in the postneurotic period,” Zh. Vyssh. Nerv. Deyat., No. 1, 97 (1973).Google Scholar
  6. 6.
    V. V. Zakusov, Pharmacology of Central Synapses [in Russian], Meditsina, Moscow (1973), p. 272.Google Scholar
  7. 7.
    N. N. Zakharova, “Effect of psychotropic drugs in emotional stress,” Zh. Nevropat. i Psikhiat., No. 2, 277 (1974).Google Scholar
  8. 8.
    N. A. Plokhinskii, Biometrics [in Russian], Izd. MGU, Moscow (1970), p. 366.Google Scholar
  9. 9.
    V. I. Savchuk, “Physiological investigation of the action of haloperidol on the higher levels of the brain,” Trudy Moskovsk. Nauch. Issled. Inst. Psikhiat.,49, 327 (1967).Google Scholar
  10. 10.
    A. I. Sikharulidze, “The action of trifluoperazine on higher nervous activity in dogs,” Azerbaidzhan. Med. Zh., 24 (1964).Google Scholar
  11. 11.
    E. Z. Frishman, “The effect of mental stress on the perception of time by man,” in: New Research in Psychology [in Russian], Pedagogika, Moscow (1973), p. 5.Google Scholar
  12. 12.
    D. D. Sherman, “The phenomenon of unequal purposiveness of adaptive responses in the process of activity during severe stress,” in: Stress and Its Pathogenetic Mechanisms [in Russian], Kishinev (1973), pp. 114–115.Google Scholar
  13. 13.
    R. S. Snider and W. T. Niemer, A Stereotaxic Atlas of the Cat Brain, Chicago (1961).Google Scholar
  14. 14.
    G. Weltman, R. A. Christianson, and G. H. Egstrom, “Effect of environment and experience on underwater work performance,” Human Factors,12, 587 (1970).Google Scholar

Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • R. M. Salimov
    • 1
  1. 1.Laboratory of Pharmacotherapy of Extremal States, Department of Pharmacology, Institute of PharmacologyAcademy of Medical Sciences of the USSRMoscow

Personalised recommendations