Abstract
A factor reacting with DNA and, in 62% of cases, with dextran sulfate was found in the gamma-globulin fraction of sera from mink with Aleutian disease or with no visible evidence of it. During chromatography of mink sera on a column with Biogel P-200, only the fractions of the first peak, consisting chiefly of a component with sedimentation constant 19S, were able to react with DNA. The presence of the factor and its ability to be neutralized by DNA preparations did not correlate with the hypergammaglobulinemia and were independent of the state of the animals.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
B. M. Vagner, “Diseases of connective tissue in animals,” in: Morphological Basis of Clinical and Experimental Pathology [in Russian], Moscow (1972), p. 63.
A. Ya. Kul'berg, “Ion-exchange chromatography and gel filtration in immunology,” in: Immunochemical Analysis [in Russian], Moscow (1968), pp. 21–42.
V. A. Nasonova and A. M. Poverennyi, “Clinical assessment of determination of antibodies against deoxyribonucleic acid (DNA) by the passive hemagglutination test (PHT),” Ter. Arkh., No. 9, 38 (1967).
A. M. Poverennyi and M. I. Levi, “Investigation of the relations between the structure of DNA and its antigenic properties,” Biokhimiya, No. 1, 80 (1964).
V. K. Podgorodnichenko and A. M. Poverennyi, “Proteins (antibodies) reacting specifically with DNA injured by the action of ultraviolet radiation,” Molekul. Biol., No. 4, 483 (1967).
A. M. Poverennyi, T. L. Aleinikova, and A. S. Saenko, “Characteristics of part of the DNA molecule reacting with antibodies,” Biokhimiya, No. 6, 4150 (1966).
A. M. Poverennyi and M. I. Levi, “The existence of two types of antibodies against DNA,” Vopr. Med. Khim., No. 2, 95 (1965).
E. V. Barnett, R. C. Williams, A. J. Kenyon, et al., “Nuclear antigens and antinuclear antibodies in mink sera,” Immunology,16, 241 (1961).
H. J. Cho and D. G. Ingram, “Isolation, purification and the structure of Aleutian disease virus by immunological technique,” Nature, New Biol.,234, 174 (1973).
D. D. Porter, F. J. Dixon, and A. E. Larsen, “The development of a myeloma-like condition in mink with Aleutian disease,” Blood,25, 736 (1965).
R. C. Williams, J. D. Russell, and A. J. Kenyon, “Antigammaglobulin factors and immunofluorescent studies in normal mink and mink with Aleutian disease,” Am. J. Vet. Res.,27, 1447 (1966).
Author information
Authors and Affiliations
Additional information
Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 80, No. 8, pp. 57–60, August, 1975.
Rights and permissions
About this article
Cite this article
Vasil'eva, E.G., Podgorodnichenko, V.K., Tsyplyakovskaya, L.M. et al. Distribution of DNA-reactive serum factor in healthy mink and mink with Aleutian disease. Bull Exp Biol Med 80, 919–922 (1975). https://doi.org/10.1007/BF00789270
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00789270