Abstract
The activity of Na+−K+-adenosinetriphosphatase (Na−K-ATPase), succinate dehydrogenase (SD), lactate dehydrogenase (LD), and glucose-6-phosphate dehydrogenase (G-6-PD) was studied in the cortex and the outer and inner parts of the medulla of the kidneys of rats with spontaneous hypertension (line SHR) and control Wistar rats. No changes in the activity of the above enzymes compared with the control was found in SHR rats aged 6–8 weeks and in the prehypertensive stage. SHR rats at the age of 16–22 weeks, with persistent hypertension, differed from the control rats in their low specific Na−K-ATPase, SD, and LD activity in the tissue of the outer part of the medulla. This difference may be connected with the reduced intensity of energy metabolism and cessation of active sodium transport in the ascending limb of the loop of Henle in the SHR rats and may be responsible for the phenomenon of exaggerated sodium excretion characteristic of hypertension.
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Translated from Byuleten' Éksperimental'noi Biologii i Meditsiny, Vol. 80, No. 8, pp. 39–42, August, 1975.
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Postnov, Y.V., Reznikova, M.B. & Boriskina, G.M. Na+−K+-adenosinetriphosphatase and certain oxidoreductases in the kidney of rats with spontaneous hypertension. Bull Exp Biol Med 80, 896–899 (1975). https://doi.org/10.1007/BF00789264
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DOI: https://doi.org/10.1007/BF00789264