Acute cell death induced by inhibition of DNA synthesis in various parts of the gastrointestinal tract
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Injection of hydroxyurea into mice led after 4 h to degeneration of nearly all DNA-synthesizing cells in the crypts of the small intestine, but only about 10% of these cells in the epithelium of the glandular part of the stomach underwent necrosis under these conditions. Hydroxyurea inhibited DNA synthesis equally in both tissues. The resistance of the gastric cells, as shown by the criterion of acute death, reflected their ability to with-stand inhibition of DNA synthesis without degeneration. This property is perhaps preserved in tumors of the stomach and may be one factor determining their resistance to chemotherapy.
Key Wordsstomach intestine DNA synthesis hydroxyurea cell death
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