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Changes in the morphology of connective tissue explantates in rats treated with methylcholanthrene and extract from a human lung tumor

  • Microbiology and Immunity
  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

The authors studied the morphology of connective tissue explants in rats subjected to the combined effect of methylcholanthrene and extract of cancer tissue of human lung.

In 4 months and more, stable changes of the growth zone structure were revealed, as well as a large number of multinuclear giant cells.

These changes were retained during culture for two years.

It is suggested that malignant change occurred in the connective tissue cultures of rats.

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Literature Cited

  1. O. K. Ashmarina, Vopr. Onkol.,2, 2, 211 (1956).

    Google Scholar 

  2. S. V. Benevolenskaya, Arkh. Patol. 5, 7 (1948).

    Google Scholar 

  3. S. V. Benevolenskaya, Med. Zhur. Ukrain.,21, 3, 21 (1951).

    Google Scholar 

  4. S. V. Benevolenskaya, Abstracts of Scientific Proceedings of the Tenth Session of the General Council of the AMN SSSR, (Moscow, 1956), p. 36 [In Russian].

  5. S. V. Benevolenskaya, in: Problems of the Etiology and Pathogenesis of Tumors (Moscow, 1957), p. 55 [in Russian].

  6. R. B. Gragerova and O. K. Ashmarina, in: Problems of the Etiology and Pathogenesis of Tumors (Moscow, 1957), p. 133 [In Russian].

  7. A. M. Eroshkina, A. S. Shubin, and V. G. Proshchenko, in: Problems of the Etiology and Pathogenesis of Tumors (Moscow, 1957), p. 99 [In Russian].

  8. Z. I. Merekalova, G. A. Piskunova, F. I. Leikine, et al., in: Problems of the Etiology and Pathogenesis of Tumors (Moscow, 1957), p. 125 [In Russian].

  9. M. T. Mogila, in: Problems of the Etiology and Pathogenesis of Tumors (Moscow, 1957), p. 59 [In Russian].

  10. G. A. Piskunova, Z. I. Merekalova, V. N. Kolmykova, et al., in: Problems of the Etiology and Pathogenesis of Tumors (Moscow, 1957), p. 115 [In Russian].

  11. V. N. Ponomareva, A. S. Shubin, and L. S. Evseenko, in: Problems of the Etiology and Pathogenesis of Tumors (Moscow, 1957), p. 105 [In Russian].

  12. K. A. Sedov, in: Problems of the Etiology and Pathogenesis of Tumors (Moscow, 1957), p. 111 [In Russian].

  13. O. D. Timofeevskii, Med. Zhur. Ukrain.,24, 2, 21 (1954).

    Google Scholar 

  14. O. D. Timofeevskii and S. V. Benevolenskaya, Med. Zhur. Ukrain.20, 2, 18 (1950).

    Google Scholar 

  15. O. D. Timofeevskii and S. V. Benevolenskaya, Med. Zhur. Ukrain.22, 4, 16 (1952).

    Google Scholar 

  16. O. D. Timofeevskii and S. V. Benevolenskaya, Arkh. Patol.3, 15 (1953).

    Google Scholar 

  17. O. D. Timofeevskii and S. V. Benevolenskaya, in: Problems of the Pathogenesis and Immunology of Tumors (Moscow, 1956), p. 14 [In Russian].

  18. A. S. Shubin, in: Problems of the Etiology and Pathogenesis of Tumors (Moscow, 1957), p. 49 [In Russian].

  19. L. Dmochowski and R. D. Passey, in: The Role of Viruses in the Development of Tumors (Moscow, 1953), p. 220 [Russian translation].

  20. W. R. Earle, J. Nat. Cancer Inst.4, 165 (1943).

    Google Scholar 

  21. L. Gross, Cancer Res.18, 371 (1958).

    Google Scholar 

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Authors and Affiliations

  1. Laboratory of Tissue Culture of the Division of Etiology and Pathogenesis of Tumors of the Institute of Experimental Pathology and Therapy of Cancer, AMN SSSR, Moscow

    M. T. Mogila & Ya. V. Dobrynin

Authors
  1. M. T. Mogila
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  2. Ya. V. Dobrynin
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Mogila, M.T., Dobrynin, Y.V. Changes in the morphology of connective tissue explantates in rats treated with methylcholanthrene and extract from a human lung tumor. Bull Exp Biol Med 49, 181–183 (1960). https://doi.org/10.1007/BF00788786

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  • DOI: https://doi.org/10.1007/BF00788786

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