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Hemopoietic properties of the sera of healthy and anemic animals (cats)

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

It was demonstrated experimentally that the subcutane ous injection of sera (3–9 ml) obtained from healthy cats into recipient rabbits causes moderately marked fluctuations in the red cell count and hemoglobin level and reticulocyte count. At the height of anemias after splenic denervation both the serum and plasma contain an anemic factor which decreases the red cell count and hemoglobin level when injected into other animals and disturbs erythroblast maturation with subsequent inhibition of erythropoiesis. In similar experiments the nonprotein plasma extract causes analogous, although less pronounced changes. The serum in posthemorrhagic anemia possesses hemopoietic activity and causes moderate polyglobulonemia and pronounced reticulocytosis in recipient rabbits.

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Authors and Affiliations

  1. Laboratory of Experimental Pathology and Therapy, Leningrad Institute of Tuberculosis, Leningrad, USSR

    E. L. Kan

  2. Group Directed by Active Member AMN SSSR M. D. Tushinskii, USSR

    E. L. Kan

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  1. E. L. Kan
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Kan, E.L. Hemopoietic properties of the sera of healthy and anemic animals (cats). Bull Exp Biol Med 49, 148–152 (1960). https://doi.org/10.1007/BF00788777

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  • DOI: https://doi.org/10.1007/BF00788777

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