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Basic Research in Cardiology

, Volume 89, Issue 2, pp 101–117 | Cite as

Some aspects of cardiac heterogeneity

  • H-G Zimmer
Editorial
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Summary and conclusion

It is remarkable that the heart, which obviously functions as a homogenous pump, shows such a high degree of heterogeneity. There are often contradictory on controversial results as far as transmural gradients are concerned (78). These discrepancies or inconsistencies, however, can at least in part be explained by species differences.

Of particular interest is the heterogeneity that is due to the separation into two hearts. In view of the differences in the morphology and function of the left and right heart, it is surprising that the whole organ works in a rather homogenous fashion. In the past, the right heart has received not as much attention as the left heart. This is in particular true for small laboratory animals. It becomes more and more evident that compared to the left ventricle, the right ventricle reacts to various stimuli in a quantitatively different manner. More research on the right heart is therefore needed.

Collectively, the data summarized in this article may be interpreted in that the heart not only works as a homogeneous unit, but may even benefit from the heterogeneity of its different parts or subunits under normal as well as under various pathophysiological conditions. Analysis of the processes involved in creating cardiac heterogeneity can provide new insights into the mechanism of adaptation of the heart.

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References

  1. 1.
    Allison TB, Ramey CA, Holsinger JW (1977) Transmural gradients of left ventricular metabolites after circumflex artery ligation in dogs. J Mol Cell Cardiol 9: 837–852Google Scholar
  2. 2.
    Arias-Stella J, Recavarren S (1962) Right ventricular hypertrophy in native children living at high altitude. Am J Pathol 41: 55–64Google Scholar
  3. 3.
    Arias-Stella J, Saldana M (1963) The terminal portion of the pulmonary arterial tree in people native to high altitudes. Circulation 28: 915–925Google Scholar
  4. 4.
    Armour JA, Randall WC (1970) Structural basis for cardiac function. Am J Physiol 218: 1517–1523Google Scholar
  5. 5.
    Armour JA, Pace JB, Randall WC (1970) Interrelationship of architecture and function of the right ventricle. Am J Physiol 218: 174–179Google Scholar
  6. 6.
    Ball RM, Bache RJ, Cobb FR, Greenfield JC (1975) Regional myocardial blood flow during graded treadmill exercise in the dog. J Clin Invest 55: 43–49Google Scholar
  7. 7.
    Ball RM, Bache RJ (1976) Distribution of myocardial blood flow in the exercising dog with restricted coronary artery inflow. Circ Res 38: 60–66Google Scholar
  8. 8.
    Basile C, Tota B (1971) Distribuzione degli isoenzimi della lattico-deidrogenasi nelle diverse parti del miocardio bovino. Boll Soc Ital Cardiol 16: 788–794Google Scholar
  9. 9.
    Bolli R, Patel BS, Hartley CJ, Thornby JI, Jeroudi MO, Roberts R (1989) Nonuniform transmural recovery of contractile function in stunned myocardium. Am J Physiol 257: H374-H385Google Scholar
  10. 10.
    Bouman LN, Jongsma HJ (1986) Structure and function of the sino-atrial node: A review. Eur Heart J 7: 94–104Google Scholar
  11. 11.
    Braunwald E, Kloner RA (1982) The stunned myocardium: Prolonged, postischemic ventricular dysfunction. Circulation 66: 1146–1149Google Scholar
  12. 12.
    Brutsaert DL (1987) Nonuniformity: A physiologic modulator of contraction and relaxation of the normal heart. J Am Coll Cardiol 9: 341–348Google Scholar
  13. 13.
    Brutsaert DL, Andries LJ (1992) The endocardial endothelium. Am J Physiol 263: H985-H1002Google Scholar
  14. 14.
    Buckberg GD, Fixler DE, Archie JP, Hoffman JIE (1972) Experimental subendocardial ischemia in dogs with normal coronary arteries. Circ Res 30: 67–81Google Scholar
  15. 15.
    Burnett JC, Kao PC, Hu DC, Heser DW, Heublein D, Granger JP, Opgenorth TJ, Reeder GS (1986) Atrial natriuretic peptide elevation in congestive heart failure in the human. Science 231: 1145–1147Google Scholar
  16. 16.
    Camici P, Ursini F, Galiazzo F, Bellitto L, Pelosi G, Marzilli M, L'Abbate A, Barsacchi R (1984) Different respiratory activities of mitochondria isolated from the subendocardium and subepicardium of the canine heart. Basic Res Cardiol 79: 454–460Google Scholar
  17. 17.
    Chilian WM (1991) Microvascular pressure and resistances in the left ventricular subepicardium and subendocardium. Circ Res 69: 561–570Google Scholar
  18. 18.
    Cohen I, Giles W, Noble D (1976) Cellular basis for the T wave of the electrocardiogram. Nature 262: 657–661Google Scholar
  19. 19.
    Davies F, Francis ETB, Stoner HB (1947) The distribution of nucleotide, phosphocreatine, and glycogen in the heart. J Physiol 106: 154–166Google Scholar
  20. 20.
    DeBold AJ, Borenstein HB, Veress AT, Sonnenberg H (1981) A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. Life Sci 28: 89–94Google Scholar
  21. 21.
    Deussen A, Walter C, Borst M, Schrader J (1991) Transmural gradient of adenosine in canine heart during functional hyperemia. Am J Physiol 260: H671-H680Google Scholar
  22. 22.
    Dunn RB, Griggs DM (1975) Transmural gradients in ventricular tissue metabolites produced by stopping coronary blood flow in the dog. Cire Res 37: 438–445Google Scholar
  23. 23.
    Eisenberg BR, Edwards JA, Zak R (1985) Transmural distribution of isomyosin in rabbit ventricle during maturation examined by immunofluorescence and staining for calcium-activated adenosine triphosphatase. Circ Res 56: 548–555Google Scholar
  24. 24.
    Endo M, Hiramoto T, Ishihata A, Takanashi M, Inui J (1991) Myocardial α1 mediate positive inotropic effect and changes in phosphatidylinositol metabolism. Species differences in receptor distribution and the intracellular coupling process in mammalian ventricular myocardium. Circ Res 68: 1179–1190Google Scholar
  25. 25.
    von Euler US, Liljestrand G (1947) Observations on the pulmonary arterial pressure in the cat. Acta Physiol Scand 12: 301–320Google Scholar
  26. 26.
    Feiring AJ, Rumberger JA, Reiter SJ, Collins SM, Skorton DJ, Rees M, Marcus ML (1988) Sectional and segmental valiability of the left ventricular function: Experimental and clinical studies using ultrafast computed tomography. J Am Coll Cardiol 12: 415–425Google Scholar
  27. 27.
    Flameng W, Suy R, Schwarz F, Borgers M, Piessens J, Thone F, van Ermen H, De Geest H (1981) Ultrastructural correlates of left ventricular contraction abnormalities in patients with chronic ischemic disease: Determinants of reversible segmental asynergy postrevascularization surgery. Am Heart J 102: 846–857Google Scholar
  28. 28.
    Flink IL, Rader JH, Banerjee SK, Morkin E (1978) Atrial and ventricular cardiac myosine contain different heavy chain species. FEBS Lett 94: 125–130Google Scholar
  29. 29.
    Furukawa T, Myerburg RJ, Furukawa N, Bassett A, Kimura S (1990) Differences in transient outward currents of feline endocardial and epicardial myocytes. Circ Res 67: 1287–1291Google Scholar
  30. 30.
    Gerdes AM, Moore JA, Bishop SP (1985) Failure of propranolol to prevent chronic hyperthyroid induced cardiac hypertrophy and multifocal cellular necrosis in the rat. Can J Cardiol 1: 340–345Google Scholar
  31. 31.
    Gilmour RF, Zipes DP (1980) Different electrophysiological responses of canine endocardium and epicardium to combined hyperkalemia, hypoxia, and acidosis. Circ Res 46: 814–825Google Scholar
  32. 32.
    Heyndrickx GR, Millard RW, McRitchie RJ, Maroko PR, Vatner SF (1975) Regional myocardial functional and electrophysiological alterations after brief coronary artery occlusion in conscious dogs. J Clin Invest 56: 978–985Google Scholar
  33. 33.
    Hittinger L, Shannon RP, Kohin S, Manders WT, Kelly P, Vatner SF (1990) Exercise-induced subendocardial dysfunction in dogs with left ventricular hypertrophy. Circ Res 66: 329–343Google Scholar
  34. 34.
    Hittinger L, Shen Y-T, Patrick TA, Hasebe N, Komamura K, Ihara T, Manders WT, Vatner SF (1992) Mechanism of subendocardial dysfunction in response to exercise in dogs with severe left ventricular hypertrophy. Circ Res 71: 423–434Google Scholar
  35. 35.
    Hurtado A (1964) Animals in high altitudes: resident man. In: Handbook of Physiology, (Cill DB, ed.), American Physiological Society, Washington, D.C., pp 843–860Google Scholar
  36. 36.
    Irlbeck M, Zimmer H-G (1993) Acute effects of catecholamines on function of the rat right heart. Cardiovasc Res 27: 2146–2151Google Scholar
  37. 37.
    Irlbeck M, Mühling O, Zimmer H-G (1993) Chronic effects of norepinephrine on rat right and left ventricle. Pflügers Arch 422 (Suppl. 1), 359, R 98 (abstract)Google Scholar
  38. 38.
    Izumo S, Nadal-Ginard B, Mahdavi V (1988) Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload. Proc Natl Acad Sci USA 85: 339–343Google Scholar
  39. 39.
    Jedeikin LA (1964) Regional distribution of glycogen and phosphorylase in the ventricles of the heart. Circ Res 14: 202–211Google Scholar
  40. 40.
    Keith A (1924) Fate of the bulbus cordis in the human heart. Lancet 2: 1267–1273Google Scholar
  41. 41.
    Kirk ES, Honig CR (1964) Nonuniform distribution of blood flow and gradients of oxygen tension within the heart. Am J Physiol 207: 661–668Google Scholar
  42. 42.
    Kisch B (1956) Electron microscopy of the atrium of the heart. I. Guinea pig. Exp Med Surg 14: 99–112Google Scholar
  43. 43.
    Kübler W, von Smekal P, Schumacher K, Gerhard W (1969), Vergleichende Untersuchungen über das Enzymverteilungsmuster im Reizleitungssystem und im Arbeitsmyokard Verth Dtsch Ges Kreislaufforsch 35: 169–174Google Scholar
  44. 44.
    Leipälä JA, Takala TES, Hassinen IE (1989) Transmural distribution of calcium accumulation and glucose uptake in the calcium paradox in the rat left ventricle. J Mol Cell Cardiol 21: 841–848Google Scholar
  45. 45.
    Linzbach AJ (1960) Heart failure from the point of view of quantitative anatomy. Am J Cardiol 5: 370–382, 1960Google Scholar
  46. 46.
    Litovsky SH, Antzelevitch C (1988) Transient outward current prominent in canine ventricular epicardium but not endocardium. Circ Res 62: 116–126Google Scholar
  47. 47.
    Long L, Fabian F, Mason DT, Wikman-Coffelt J (1977) A new cardiac myosin characterized from the canine atria. Biochem Biophys Res Comm 76: 626–635Google Scholar
  48. 48.
    Lundsgaard-Hansen P, Meyer C, Riedwyl H (1967) Transmural gradient of glycolytic enzyme activities in left ventricular myocardium. I The Normal State. Pflügers Arch 297: 89–106Google Scholar
  49. 49.
    March HW, Ross JK, Lower RR (1962) Observations on the behavior of the right ventricular outflow tract, with references to its developmental origins. Am J Med 32: 835–845Google Scholar
  50. 50.
    Mercadier J-J, Lompré A-M, Wisnewsky C, Samuel J-L, Bercovici J, Swynghedauw B, Schwartz K (1981) Myosin isoenzymic changes in several models of rat cardiac hypertrophy. Circ Res 49: 525–532Google Scholar
  51. 51.
    Morady F, Laks MM, Parmley WW (1973) Comparison of sarcomere lengths from normal and hypertrophied inner and middle canine right ventricle. Am J Physiol 225: 1257–1259Google Scholar
  52. 52.
    Moss AJ (1968) Intramyocardial oxygen tension. Cardiovasc Res 3: 314–318Google Scholar
  53. 53.
    Moulder PV, Eichelberger L, Rams JJ, Greenburg AG (1966) Water, nitrogen, and electrolyte content of right and left ventricular walls and interventricular septum of normal canine hearts. Circ Res 19: 662–667Google Scholar
  54. 54.
    Prinzen FW, Augustijn CH, Allessie MA, Arts T, Delhaas T, Reneman RS (1992) The time sequence of electrical and mechanical activation during spontaneous beating and ectopic stimulation. Eur Heart J 13: 535–543Google Scholar
  55. 55.
    Raines RA, LeWinter MM, Covell JW (1976) Regional shortening pattern in canine right ventricle. Am J Physiol 231: 1395–1400Google Scholar
  56. 56.
    Reimer KA, Jennings RB (1979) The “wavefront phenomenon” of myocardial ischemic cell death. II. Transmural progression of necrosis within the framework of ischemic bed size (myocardium at risk) and collateral flow. Lab Invest 40: 633–644Google Scholar
  57. 57.
    Rockman HA, Ross RS, Harris AN, Knowlton KU, Steinhelper ME, Field LJ, Ross J, Chien KR (1991) Segregation of atrialspecific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy. Proc Natl Acad Sci USA 88: 8277–8281Google Scholar
  58. 58.
    Rotta A, Canepa A, Hurtado A, Velasquez T, Chavez R (1956) Pulmonary circulation at sea level and at high altidues. J Appl Physiol 9: 328–336Google Scholar
  59. 59.
    Saari JT, Johnson JA (1980) Calcium kinetics in individual heart segments. Cardiovas Res 14: 731–734Google Scholar
  60. 60.
    Sabbah HN, Marzilli M, Stein PD (1981) The relative role of subendocardium and subepicardium in left ventricular mechanics. Am J Physiol 240: H920-H926Google Scholar
  61. 61.
    Saito K, Tamura Y, Saito M, Matsumara K, Niki T, Mori H (1981) Comparison of the subunit compositions and ATPase activities of myosin in the myocardium and conduction system. J Mol Cell Cardiol 13: 311–322Google Scholar
  62. 62.
    Sartore S, Pierobon-Bormiolo S, Schiaffino S (1978) Immunohistochemical evidence for myosin polymorphism in the chicken heart. Nature 274: 82–83Google Scholar
  63. 63.
    Schiaffino S, Samuel JL, Sassoon D, Lompré AM, Garner I, Marotte F, Buckingham M, Rappaport L, Schwartz K (1989) Nonsynchronous accumulation of α-skeletal actin and β-myosin heavy chain mRNAs during early stages of pressure-overload-induced cardiac hypertrophy demonstrated by in situ hybridization. Circ Res 64: 937–948Google Scholar
  64. 64.
    Schrör K, Sadat-Khonsari A, Krebs R (1979) Different intracellular cation-content present in right and left ventricle dependent on varying extracellular Ca2+-concentrations. J Mol Cell Cardiol 11: 45–55Google Scholar
  65. 65.
    Shore PA, Cohn VH, Higman B, Maling HM (1958) Distribution of norepinephrine in the heart. Nature 181: 848–849Google Scholar
  66. 66.
    Sicouri S, Antzelevitch C (1991) A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle. The M cell. Circ Res 68: 1729–1741Google Scholar
  67. 67.
    Sommer JR, Johnson EA (1968) Cardiac muscle. A comparative study of purkinje Fibers and ventricular fibers. J Cell Biol 36: 497–526Google Scholar
  68. 68.
    Sonnenberg H (1987) On the physiological role of atrial natriuretic factor. Klin Wschr 65 (Suppl VIII): 8–13Google Scholar
  69. 69.
    Spotniz HM, Sonnenblick EH, Spiro D (1966) Relation of ultrastructure to function on the intact heart: Sarcomere structure relative to pressure volume curves of intact left ventricles of dog and cat. Circ Res 18: 49–66Google Scholar
  70. 70.
    Stein PD, Marzilli M, Sabbah HN, Lee T (1980) Systolic and diastolic pressure gradients within the left ventricular wall. Am J Physiol 238: H625-H630Google Scholar
  71. 71.
    Takala TES, Hassinen IE (1981) Effect of mechanical work load on the transmural distribution of glucose uptake in the isolated perfused rat heart, studied by regional deoxyglucose trapping. Circ Res 49: 62–69Google Scholar
  72. 72.
    Takala TES, Ruskoaho HJ, Hassinen IE (1983) Transmural distribution of cardiac glycose uptake in rat during physical exercise. Am J Physiol 244: H131-H137Google Scholar
  73. 73.
    Takala TES, Pirttisalo JA, Hiltunen JK, Hassinen IE (1984) Effects of substrate supply and aortic pressure on the transmural distribution of glucose uptake in the isolated perfused rat heart. J Mol Cell Cardiol 16: 567–571Google Scholar
  74. 74.
    Tennant R, Wiggers CJ (1935) The effect of coronary occlusion on myocardial contraction. Am J Physiol 112: 351–361Google Scholar
  75. 75.
    Thibault G, Garcia R, Seidah NG, Lazure C, Cantin M, Chrétien M, Genest J (1983) Purification of three rat atrial natriuretic factors and their amino acid composition. FEBS Letters 164: 286–290Google Scholar
  76. 76.
    Tota B (1973) On the regional metabolism of beef heart ventricles. Acta Physiol scand 87: 289–295Google Scholar
  77. 77.
    Urthaler F, Walker AA, Hefner LI, James TN (1975) Comparison of contractile performance of canine atrial and ventricular muscles. Circ Res 37: 762–771Google Scholar
  78. 78.
    Van der Vusse GJ, Arts T, Glatz JFC, Reneman RS (1990) Transmural differences in energy metabolism of the left ventricular myocardium: Fact or fiction. J Mol Cell Cardiol 22: 23–37Google Scholar
  79. 79.
    Van Liere EJ, Sizemore DA, Hunnel J (1969) Size of cardiac ventricles in experimental hyperthyroidism in the rat. Proc Soc Exp Biol Med 132: 663–665Google Scholar
  80. 80.
    Watanabe T, Delbridge LM, Bustamante JO, McDonald TF (1983) Heterogeneity of the action potential in isolated rat ventricular myocytes and tissue. Circ Res 52: 280–290Google Scholar
  81. 81.
    Watson RM, Markle DR, Ro YM, Goldstein SR, McGuire DA, Peterson JI, Patterson RE (1984) Transmural pH gradient in canine myocardial ischemia. Am J Physiol 246: H232-H238Google Scholar
  82. 82.
    Weisberg J, Rodbard S (1958) Distribution of glycogen in the rat heart. Am J Physiol 193: 466–468Google Scholar
  83. 83.
    Weiss HR, Neubauer JA, Lipp JA, Sinha AK (1978) Quantitative determination of regional oxygen consumption in the dog heart. Circ Res 42: 394–401Google Scholar
  84. 84.
    Yazaki Y, Ueda S, Nagai R, Shimada K (1979) Cardiac atrial myosin adenosine triphosphatase of animals and humans. Distinctive enzymatic properties compared with cardiac ventricular myosin. Circ Res 45: 522–527Google Scholar
  85. 85.
    Yoran C, Covell JW, Ross J (1973) Structural basis for the ascending limb of left ventricular function. Circ Res 32: 297–303Google Scholar
  86. 86.
    Zierhut W, Zimmer H-G (1989) Effect of calcium antagonists and other drugs on the hypoxia-induced increase in rat right ventricular pressure. J Cardiovasc Pharmacol 14: 311–318Google Scholar
  87. 87.
    Zierhut W, Zimmer H-G (1989) Differential effects of triiodothyronine on rat left and right ventricular function and the influence of metoprolol. J Mol Cell Cardiol 21: 617–624Google Scholar
  88. 88.
    Zimmer H-G, Gerdes AM, Lortet S, Mall G (1990) Changes in heart function and cardiac cell size in rats with chronic myocardial infarction. J. Mol Cell Cardiol 21: 1231–1243Google Scholar
  89. 89.
    Zimmer H-G, Ibel H (1983) Effects of ribose on cardiac metabolism and function in isoproterenoltreated rats. Am J Physiol 245: H880-H886Google Scholar
  90. 90.
    Zimmer H-G, Zierhut W, Seesko RC, Varekamp AE (1988) Right heart catheterization in rats with pulmonary hypertension and right ventricular hypertrophy. Basic Res Cardiol 83: 48–57Google Scholar
  91. 91.
    Zimmerman ANE, Hülsmann WC (1966) Paradoxical influences of calcium ions on the permeabilitiy of the cell membranes of the isolated rat heart. Nature 211: 646–647Google Scholar

Copyright information

© Steinkopff-Verlag 1994

Authors and Affiliations

  • H-G Zimmer
    • 1
  1. 1.Department of PhysiologyUniversity of MunichFRG

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