Skip to main content
SpringerLink
Log in

The leukocyte cell adhesion cascade and its role in myocardial ischemia-reperfusion injury

  • Review
  • Published:
Basic Research in Cardiology Aims and scope Submit manuscript

Abstract

Cell-cell and cell-matrix interactions are known to be mediated by specific cell adhesion receptors expressed on the cell surface. The characterization of these cell adhesion molecules has allowed researchers to examine their roles in a variety of physiologic and pathophysiologic conditions. Numerous studies have demonstrated that myocardial ischemia-reperfusion injury is an acute inflammatory process in which leukocytes are intimately involved. In this review, we summarize the current data on the leukocyte cell adhesion cascade, focus upon studies which have demonstrated specific cell adhesion molecule interactions which mediate the leukocyte involvement in myocardial ischemia-reperfusion injury, and suggest future avenues of exploration and possible clinical implications of the studies reviewed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Albelda SM (1991) Endothelial and epithelial cell adhesion molecules. Am J Resp Cell & Mol Biol 4: 195–203

    Google Scholar 

  2. Albelda SM, Buck CA (1990) Integrins and other cell adhesion molecules. FASEB J 4: 2868–2880

    Google Scholar 

  3. Albelda SM, Muller WA, Buck CA, Newman PJ (1991) Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule. J Cell Biol 114: 1059–1068

    Google Scholar 

  4. Anderson DC, Schmalsteig FC, Finegold MJ, Hughes BJ, Rothlein R, Miller LJ, Kohl S, Tosi MF, Jacobs RL, Waldrop TC, Goldman AS, Shearer WT, Springer TA (1985) The severe and moderate phenotypes of heritable Mac-1, LFA-1 deficiency: their quantitative definition and relation to leukocyte dysfunction and clinical features. J Infect Dis 152: 668–689

    Google Scholar 

  5. Arfors K-E, Lundberg C, Lindbom L, Lindberg K, Beatty PG, Harlan JM (1987) A monoclonal antibody to the membrane glycoprotein complex CD18 inhibits polymorphonuclear leukocyte accumulation and plasma leakage in vivo. Blood 69: 367–371

    Google Scholar 

  6. Arnaout MA (1990) Structure and function of the leukocyte adhesion molecule CD11/CD18. Blood 75: 1037–1050

    Google Scholar 

  7. Arnaout MA, Lanier LL, Faller DV (1988) Relative contribution of the leukocyte molecules Mol, LFA-1, and pl50,95 (LeuM5) in adhesion of granulocytes and monocytes to vascular endothelium is tissue-and stimulus-specific. J Cell Physiol 137: 305–309

    Google Scholar 

  8. Aversano T, Zhou W, Nedelman M, Nakada M, Weisman H (1995) A chimeric IgG4 monoclonal antibody directed against CD18 reduces infarct size in a primate model of myocardial ischemia and reperfusion. J Am Coll Card 25: 781–788

    Google Scholar 

  9. Barnard JW, Biro MG, Lo SK, Ohno S, Carozza MA, Moyle M, Soule HR, Malik AB (1995) Neutrophil inhibitory factor prevents neutrophil-dependent lung injury. J Immun 155: 4876–4881

    Google Scholar 

  10. Bauer C, Siaplaouras S, Soule HR, Moyle M, Marzi I, (1995) A natural glycoprotein inhibitor (NIF) of CD11b/CD18 reduces leukocyte adhesion in the liver after hemorrhagic shock. Shock 4: 187–192

    Google Scholar 

  11. Bienvenu K, Granger DN (1993) Molecular determinants of shear rate-dependent leukocyte adhesion in postcapillary venules. Am J Physiol 2664: H1504

    Google Scholar 

  12. Bogen S, Pak J, Garifallou M, Deng X, Muller WA (1994) Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammationin vivo. J Exp Med 179: 1059–1064

    Google Scholar 

  13. Bogen SA, Baldwin HS, Watkins SC, Albelda SM, Abbas AK (1992) Association of murine CD31 with transmigrating lymphocytes following antigenic stimulation. Am J Path 141: 843–854

    Google Scholar 

  14. Buerke M, Weyrich AS, Zheng Z, Gaeta FCA, Forrest MJ, Lefer AM (1994) Sialyl lewis-x-containing oligosaccharide attenuates myocardial reperfusion injury in cats. J Clin Invest 93: 1140–1148

    Google Scholar 

  15. Carlos TM, Harlan JM (1990) Membrane proteins involved in phagocyte adherence to endothelium. Immunol Rev 114: 5–28

    Google Scholar 

  16. Carlos TM, Harlan JM (1994) Leukocyte-endothelial cell adhesion molecules. Blood 84: 2069–2101

    Google Scholar 

  17. Carlos TM, Schwartz BR, Kovach NL, Yee E, Rosa M, Osborn L, Chi-Rosso G, Newman B, Lobb R, Rosa M et al. (1990) Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells. Blood 76: 965–970

    Google Scholar 

  18. Dau PC, Callahan JP (1994) Immune modulation during treatment of systemic sclerosis with plasmapheresis and immunosuppressive drugs. Clin Immun Immunopath 70: 159–165

    Google Scholar 

  19. Davenpeck KL, Gauthier TW, Lefer AM (1994) Inhibition of endothelial-derived nitric oxide promotes P-selectin expression and actions in the rat microcirculation. Gastroenterology 107: 1050–1058

    Google Scholar 

  20. De Caterina R, Libby P, Peng HB, Thannickal VJ, Rajavashisth TB, Gimbrone MA Jr, Shin WS, Liao JK (1995) Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Invest 96: 60–68

    Google Scholar 

  21. de Fougerolles AR, Springer TA (1992) Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes. J Exp Med 175: 185–190

    Google Scholar 

  22. Dreyer WJ, Michael LH, West SW, Smith CW, Rothlein R, Rossen RD, Anderson DC, Entman ML (1991) Neutrophil accumulation in ischemic canine myocardium: insights into the time course, distribution and mechanism of localization during dearly reperfusion. Circulation 84: 400–411

    Google Scholar 

  23. Dutrochet M (1824) Recherches anatomiques et physiologiques sur la structure intime des animaux et des vegetaux, et sur Leur Motilite. Bailiere et Fils, Paris

    Google Scholar 

  24. Egbertson MS, Cheng CT-C, Duggan ME, Gould RJ, Halczenko W, Hartman GD, Laswel WL, Lynch JJ, Lynch RJ, Manno PD, Naylor AM, Prugh JD, Ranjit DR, Sitko GR, Smith RS, Turchi RS, Zhang G (1994) Non-peptide fibrinogen receptor antagonists 2. Optimization of a tyrosine template as a mimic for Arg-Gly-Asp. J Med Chem 37: 2537–2551

    Google Scholar 

  25. Engler RL, Dahlgren MD, Morris DD, Peterson MA, Schmid-Schonbein GW (1986) Role of leukocytes in response to acute myocardial ischemia and reflow in dogs. Am J Phy 251: H314–323

    Google Scholar 

  26. Entman ML, Michael L, Rossen RD, Dreyer WJ, Anderson DC, Taylor AA, Smith CW (1991) Inflammation in the course of early myocardial ischemia. FASEB J 5: 2529–2537

    Google Scholar 

  27. Entman ML, Yourker K, Shappel SB, Siegel C, Rothlein R, Dreyer WJ, Schmalsteig FC, Smith CW (1990) Neutrophil adherence to isolated adult canine myocytes: evidence for a CD18-dependent mechanism. J Clin Invest 85: 1497–1506

    Google Scholar 

  28. Entman ML, Yourker K, Shoji T (1992) Neutrophil induced oxidative injury of cardiac myocytes: a compartmented system requiring CD11b/CD18-ICAM-1 adherence. J Clin Invest 90: 1335–1345

    Google Scholar 

  29. Etzioni A, Frydman M, Pollack S, Avidor I, Phillips ML, Paulson JC, Gershoni-Baruch R (1992) Brief report: recurrent severe infections caused by a novel leukocyte adhesion deficiency. N Engl J Med 327: 1789–1792

    Google Scholar 

  30. Geffner JR, Trevani AS, Malchiodi E, Serebrinsky GP, Istuiz MA (1993) Neutrophil cytotoxicity induced by immune complex prepared with cationized antibodies. Scand J Immunol 37: 187–193

    Google Scholar 

  31. Gill EA, Kong Y, Horwitz LD (1996) An oligosaccharide sialyl-Lewisx analogue does not reduce myocardial infarct size after ischemia and reperfusion in dogs. Circulation 94: 542–546

    Google Scholar 

  32. GISSI (1986) Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Lancet 1: 397–402

    Google Scholar 

  33. Gumina RJ, Schultz J, Yao Z, Kenny D, Warltier DC, Gross GJ, Newman PJ (1995) Antibody to PECAM-1 reduces myocardial infarct size. J Invest Med 43: 312A

    Google Scholar 

  34. Harlan JM (1993) Leukocyte adhesion deficiency syndrome: insights into the molecular basis of leukocyte emigration. Clin Immunol Immunopath 67: S16

    Google Scholar 

  35. Harlan JM, Killen PD, Senecal FM, Schwartz BR, Yee EK, Taylor RF, Beatty PG, Price TH, Ochs HD (1985) The role of neutrophil membrane glycoprotein GP-150 in neutrophil adherence to endothelium in vitro. Blood 66: 167–178

    Google Scholar 

  36. Harrington RA, Kleiman NS, Kottke-Marchant K, Lincoff AM, Tcheng JE, Sigmon KN, Joseph D, Rios G, Trainor K, Rose D, Greenberg CS, Kitt MM, Topol EJ, Califf RM (1995) Immediate and reversible platelet inhibition after intravenous administration of a peptide glycoprotein IIb/IIIa inhibitor during percutaneous coronary intervention. Am J Card 76: 1222–1227

    Google Scholar 

  37. Hartman GD, Egbertson SM, Halczenko W, Laswel WL, Duggan ME, Smith RL, Naylor AM, Manno PD, Lynch RJ, Zhang G, Chang CTC, Gould RJ (1992) Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors. J Med Chem 35: 4640–4642

    Google Scholar 

  38. Hattori R, Hamilton KK, Fugate RD, McEver RP, Sims PJ (1989) Stimulated secretion of endothelial von Willebrand factor is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein GMP-140. J Biol Chem 264: 7768–7771

    Google Scholar 

  39. Haug CE, Colvin RB, Delmonico FL Jr. HA, Rolkoff-Rubin N, Preffer FT, Rothlein R, Norris S, Scharschmidt L, Cosimi AB (1993) A phase I trial of inmunosuppression with anti-ICAM-1 (CD54) mAb in renal allograft recipients. Transplantation 55: 766–773

    Google Scholar 

  40. Hearse DJ, Bolli R (1992) Reperfusion injury: manifestations, mechanisms, and clinical relevance. Cardiovascular Research 26: 101–108

    Google Scholar 

  41. Huber AR, Kunkel SL, Todd RF, Weiss SJ (1991) Regulation of transendothelial migration by endogenous interleukin-8. Science 254: 99–102

    Google Scholar 

  42. The IMPACT Investigators (1994) Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty. N Engl J Med 330: 956–961

    Google Scholar 

  43. Ioculano M, Squidrito F, Altavilla D, Canale P, Squidrito G, Campo GM, Saitta A, Caputi AP (1994) Antibodies against intercellular adhesion molecenic 1 protect against myocardial ischemia-reperfusion injury in rat. Eur J Pharm 264: 143–149

    Google Scholar 

  44. Jones EY, Harlos K, Bottomley MJ, Robinson RC, Driscoll PC, Edwards RM, Clements JM, Dudgeon TJ, Stuart DI (1995) Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 A resolution. Nature 373: 539–544

    Google Scholar 

  45. Kereiakes DJ, NSK, Ambrose J, Cohen M, Rodriguez S, Palabrica T, Herrmann HC, Sutton JM, Weaver WD, McKee DB, Fitzpatrick V, Sax FL (1996) Randomized, double-bund, placebo-controlled dose-ranging study of tirofiban (MK-383) platelet IIb/IIIa blockade in high risk patients undergoing coronary angioplasty. J Am Coll Card 27: 536–542

    Google Scholar 

  46. Kishimoto TK, Anderson DC (1992) The role of integrins in inflammation. In: Gallin J, Goldstein I, Snyderman R (eds) Inflammation: Basic Principles and Clinical Correlates. Raven, New York, New York, p 353

    Google Scholar 

  47. Ko WA, Hawes AS, Lazenby WD, Calveno SE, Shin YT, Zelano JA, Antonacci AC (1991) Platelet activating factor stimulates polymorphonuclear leukocyte hydrogen peroxide production during myocardial reperfusion. J Thorac Cardiovase Surg 102: 297–308

    Google Scholar 

  48. Kubes P, Suzuki M, Granger DN (1991) Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 88: 4651–4655

    Google Scholar 

  49. Kuijpers TW, Hajjert BC, Hart MHL, Roos D (1992) Neutrophil migration across monolayers of cytokine-prestimulated endothelial cells: A role for platelet-activating factor and IL-8. J Cell Biol 117: 565–572

    Google Scholar 

  50. Kukielka GL, Hawkins HK, Michael LH (1993) Regulation of intercellular adhesion molecule-1 (ICAM-1) in ischemic and reperfused canine myocardium. J Clin Invest 92: 1504–1516

    Google Scholar 

  51. Kukielka GL, Manning AM, Michael LH (1993) Reperfusion is required for the injunction of cytokine and intercellular adhesion molecule-1 (ICAM-1) synthesis in ischemic hearts. Circulation (abstract) 88: 1–5

    Google Scholar 

  52. Kupatt C, Zahler S, Seligmann C, Massoudy P, Becker BF, Gerlach E (1996) Nitric oxide mitigates leukocyte adhesion and vascular leak after myocardial ischemia. J Mol Cell Card 28: 643–654

    Google Scholar 

  53. Lawrence MB, Springer TA (1991) Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins. Cell 65: 859–873

    Google Scholar 

  54. Lefer DJ, Flynn DM, Philips MI, Ratcliffe M, Buda AJ (1994) A novel sialyl Lewisx analog attenuates neutrophil accumulation and myocardial necrosis after ischemia and reperfusion. Circulation 90: 2390–2401

    Google Scholar 

  55. Lefer DJ, nakanishi K, Johnson WE, Vinten-Johansen J (1993) Antineutrophil and myocardial protecting actions of a novel nitric oxide donor after acute myocardial ischemia and reperfusion in dogs. Circulation 88: 2337–2350

    Google Scholar 

  56. Lefer DJ, Shadelya SML, Serrano CV, Becker LC, Kuppusamy P, Zweier JL (1993) Cardioprotective actions of a monoclonal antibody against CD-18 in myocardial ischemia-reperfusion injury. Circulation 88: 1779–1787

    Google Scholar 

  57. Lo SK, Lee S, Ramos RA, Lobb R, Rosa M, Chi-Rosso G, Wright SD (1991) Endothelial-leukocyte adhesion molecule 1 stimulates the adhesive activity of leukocyte integrin CR3 (CD11b/CD18, Mac-1, alpha m beta 2) on human neutrophils. J Exp Med 173: 1493–1500

    Google Scholar 

  58. Lorant DE, McEver RP, McIntyre TM, Moore KL, Prescott SM, Zimmerman GA (1995) Activation of polymorphonuclear leukocytes reduces their adhesion to P-selectin and causes redistribution of ligands for P-selectin on their surfaces. J Clin Invest 96: 171–182

    Google Scholar 

  59. Ma X, Weyrich AS, Lefer DJ, Buerke M, Albertine KH, Kishimoto TK, Lefer AM (1993) Monoclonal antibody to L-selectin attenuates neutrophil accumulation and protects ischemic reperfused cat myocardium. Circulation 88: 649–658

    Google Scholar 

  60. Ma X-I, Lefer DJ, Lefer AM, Rothlein R (1992) Coronary endothelial and cardiac protective effects of a monoclonal antibody to intercellular adhesion molecule-1 in myocardial ischemia and reperfusion. Circulation 86: 937–946

    Google Scholar 

  61. Ma X-I, Tsao PS, Lefer AM (1991) Antibody to CD-18 exerts endothelial and cardioprotective effects in myocardial ischemia and reperfusion. J Clin Invest 88: 1237–1243

    Google Scholar 

  62. Ma X-L, Weyrich AS, Krantz S, Lefer AM (1992) Mechanisms of the cardioprotective action of WEB-2170, a platelet activating factor antagonist, in myocardial ischemia and reperfusion. J Pharmacol Exp Therap 260: 1229–1236

    Google Scholar 

  63. Ma X-L, Weyrich AS, Lefer DJ, Lefer AM (1993) Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium. Circ Res 72: 403–412

    Google Scholar 

  64. Marder VJ, Sherry S (1988) Thrombolytic therapy: current status. N Engl J Med 318: 1512–1520

    Google Scholar 

  65. Mayadas TN, Johnson RC Rayburn H, Hynes RO, Wagner DD (1993) Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell 74: 541–554

    Google Scholar 

  66. McEver RP, Beckstead JH, Moore KL, Marshall-Carlson L, Bainton DF (1989) GMP-140, a platelet alphagranule membrane protein, is alse synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies. J Clin Invest 84: 92–99

    Google Scholar 

  67. Miller D, Krangel MS (1992) Biology and biochemistry of the chemokines: a family of chemotactic and inflammatory cytokines. Crit Rev Immunol 12: 17–46

    Google Scholar 

  68. Moore KL, Stults NL, Diaz S, Smith DF, Cummings RD, Varki A, McEver RP (1992) Identification of a specific glycoprotein ligand for P-selectin (CD62) on myeloid cells. J Cell Biol 118: 445–456

    Google Scholar 

  69. Moyle M, Foster DL, McGrath DE, Brown SM, Roche YL, Mentter JD, Stanssens P, Bogowitz CA, Fried VA, Ely JA, Soule HR, Vlasuk GP (1994) A hookworm glycoprotein that inhibits neutrophil function is a ligand of the integrin CD11b/CD18. J Biol Chem 269: 10008–10015

    Google Scholar 

  70. Muller WA, Weigl SA, Deng X, Phillips DM (1993) PECAM-1 is required for transendothelial migration of leukocytes. J Exp Med 178: 449–460

    Google Scholar 

  71. Murohara T, Beurke M, Lefer AM (1994) Polymorphonuclear leukocyte-induced vasoconstriction and endothelial dysfunction. Arteriosclerosis and Thrombosis 14: 1509–1519

    Google Scholar 

  72. Murohara T, Delvani JA, Albelda SM, Lefer AM (1995) Antibody to platelet endothelial cell adhesion molecule-1 (PECAM-1) protects against myocardial ischemia and reperfusion injuryin vivo. Circulation I-711

  73. Newman PJ, Berndt MC, Gorski J, White GC, Lyman S, Paddock C, Muller WA (1990) PECAM-1. (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science 247: 1219–1222

    Google Scholar 

  74. Nichols WW, Mehta JL, Donnelly WH, Lawson D, Thompson L, Reitter M (1988) Reduction in coronary vasodilator reserve following coronary occlusion and reperfusion in anesthesized dogs role of endothelium-derived relaxing factor, myocardial neutrophil infiltration and prostaglandins. J Mol Cell Cardiol 20: 943–954

    Google Scholar 

  75. Ohto H, Maeda H, Shibata Y, Chen R-F, Ozaki Y, Higashihara M, Takeuchi A, Tohyama H (1985) A novel leukocyte differentiation antigen: two monoclonal antibodies TM2 and TM3 define a 120-kd molecule present on neutrophils, monocytes, platelets, and activated lymphoblasts. Blood 66: 873–881

    Google Scholar 

  76. Patel KD, Zimmerman GA, Prescott SM, McEver RP, McIntyre TM (1991) Oxygen radicals induce human endothelial cells to express GMP-140 and bind neutrophils. J Cell Biol 112: 749–759

    Google Scholar 

  77. Peerlinck K, Lepeleire ID, Goldberg M, Farrell D, Barrett J, Hand E, Panebianco D, Deckmyn H, Vermylen J, Arnout J (1993) MK-383 (L-700,462), a selective nonpeptide platelet glycoprotein IIb/IIIa antagonist, is active in man. Circulation 88: 1512–1517

    Google Scholar 

  78. Picker LJ, Warnock RA, Burns AR, Doerschuk CM, Berg EL, Butcher EC (1991) The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140. Cell 66: 921–933

    Google Scholar 

  79. Polley MJ, Phillips ML, Warner E, Nudelman E, Singal AK, Hakomori SI, Paulson JC (1991) CD62 and endothelial cell leukocyte adhesion molecule (ELAM-1) recognize the same carbohydrate ligand, sialyl Lewis X. Proc Natl Acad Sci USA 88: 6224–6228

    Google Scholar 

  80. Rien P, Ueda T, Haruta I, Sharma C, Arnaout M (1994) The A-domain of beta 2 integrin CR3 (CD11b/CD18) is a receptor for the hookworm-derived neutrophil adhesion inhibitor NIF. J Cell Bio 127: 2081–2091

    Google Scholar 

  81. Roberts R, DeMello V, Sobel BE (1976) Deleterious effects of methylprednisone in patients with myocardial infarction. Circulation 53 (Suppl I): 204–206

    Google Scholar 

  82. Rote WE, Dempsey E, Maki S, Vlasuk GP, Moyle M (1996) The role of CD11/CD18 integrins in the reverse passive Arthus reaction in rat dermal tissue. J Leuk Biol 59: 254–261

    Google Scholar 

  83. Rothlein R, Springer TA (1986) The requirement for lymphocyte function-associated antigen 1 in homotypic leukocyte adhesion simulated by phorbol ester. J Exp Med 163: 1132–4119

    Google Scholar 

  84. Sacks T, Moldow CF, Craddock PR, Bowers TK, Jacob HS (1978) Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes: an in vitro model of immune vascular damage. J Clin Invest 61: 2620–2629

    Google Scholar 

  85. Sako D, Chang XJ, Barone KM, Vachino G, White HM, Shaw G, Veldman GM, Bean KM, Ahern TJ, Furie B, Cumming DA, Larsen GR (1993) Expression cloning of a functional glycoprotein ligand for P-selectin. Cell 75: 1179–1186

    Google Scholar 

  86. Scarborough RM, Naughton MA, Teng W, Rose JW, Phillips DR, Nasnnizzi L, Arfsten A, Campbell AM, Charo IF (1993) Design of potent and specific integrin antagonists. J Biol Chem 268: 1066–1073

    Google Scholar 

  87. Shappel SB, Toman C, Anderson DC, Taylor AA, Entman ML, Smith CW (1990) Mac-1 (CD11b/CD18) mediated adherence-dependent hydrogen peroxide production by human and canine neutrophils. J Immunol 144: 2702–2711

    Google Scholar 

  88. Sheridan FM, Cole PG, Ramage D (1996) Leukocyte adhesion to coronary microvasculature during ischemia and reperfusion in an in vivo canine model. Circulation 93: 1784–1787

    Google Scholar 

  89. Sheridan FM, Dauber IM, McMurtry IF, Lesnefsky EJ, Horowitz LD (1991) Role of leukocytes in coronary vascular endothelial injury due to ischemia and reperfusion. Circ Res 69: 1566–1574

    Google Scholar 

  90. Simpson PJ, Fantone JC, Mickelson JK, Gallagher KP, Lucchesi BR (1988) Identification of a time window for therapy to reduce experimental canine myocardial injury: suppression of neutrophil activation during 72 hours of reperfusion. Circ Res 63: 1070–1079

    Google Scholar 

  91. Simpson PJ, III TFT, Fantone JC, Mickelson JK, Griffin JD, Lucchesi BR (1988) Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-Mo-1, Anti-CD 11b) that inhibits leukocyte adhesion. J Clin Invest 81: 624–629

    Google Scholar 

  92. Sligh JE, Ballantyne CM, Rich SS, Hawkins HK, Smith CW, Bradley A, Beaudet AL (1993) Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. Proc Natl Acad Sci USA 90: 8529–8533

    Google Scholar 

  93. Smith CW (1990) Molecular determinants of neutrophil adhesion. Am J Respir Cell Mol Biol 2: 487–489

    Google Scholar 

  94. Smith CW, Marlin SD, Rothlein R, Toman C, Anderson DC (1989) Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro. J Clin Invest 83: 2008–2017

    Google Scholar 

  95. Smith CW, Rothlein R, Hughes BJ, Mariscalco MM, Rudloff HE, Schmalstieg FC, Anderson DC (1988) Recognition of an endothelial determinant for CD 18-dependent human neutrophil adherence and transendothelial migration. J Clin Invest 82: 1746–1756

    Google Scholar 

  96. Sobey CG, Dusting GJ, Grossman HJ, Woodman OL, (1990) Impaired vasodilation of epicardial coronary arteries and resistance vessels following myocardial ischemia and reperfusion in anesthesized dogs. Cor Art Dis 1: 363–374

    Google Scholar 

  97. Springer TA (1990) Adhesion receptors of the immune system. Nature 346: 425–434

    Google Scholar 

  98. Stahl GL, Terachita Z, Lefer AM (1988) Role of platelet activating factor in propagation of cardiac damage during myocardial ischemia. J Pharm Exp Therap 244: 898–904

    Google Scholar 

  99. Tanaka M, Brooks SE, Richards VJ, Fitz-Harris GP, Stoler RC, Jennings RB, Arfors KE (1993) Effect of anti-CD18 antibody on myocardial neutrophil accumulation and infarct size after ischemia and reperfusion in dogs. Circulation 87: 526–535

    Google Scholar 

  100. Tcheng JE, Harrington RA, Kottke-Marchant K, Kleiman NS, Ellis SG, Kereiakes DJ, Mick MJ, Navetta FI, Smith, JE, Worley SJ, Miller JA, Joseph DM, Sigmon KN, Kitt MM, du Mee CP, Califf RM, Topol EJ: for the IMPACT Investigators (1995) Multicenter, randomized, double-blind, placebo-controlled trial of the platelet integrelin glycoprotein IIb/IIIa blocker Integrelin in elective coronary intervention. IMPACT Investigators. Circulation 91: 2151–2157

    Google Scholar 

  101. The TIMI Study Group (1985): The Thrombolysis in Myocardial Infaration (TIMI) trial: phase I findings. N Engl J Med 312: 932–936

    Google Scholar 

  102. Topol EJ (1995) Novel antithrombotic approaches to coronary artery disease. Am J Card 75: 27B-33B

    Google Scholar 

  103. Topol EJ, Califf RM, Weisman HF, Ellis SG, Tcheng JE, Worly S, Ivanhoe R, George BS, Fintel D, Weston M, Sigmon K, Anderson KM, Lee KL, Willerson JT; on behalf of the EPIC Investigators (1994) Randomized trial of coronary intervention with antibody against platelet IIb/IIIa integrin for reduction of clinical restenosis: results at six months. Lancet 343: 881–886

    Google Scholar 

  104. Townes P, Holtfretter J (1995) Directed movements and selective adhesion of embryonic amphibian cells. J Exp Zool 128: 53–120

    Google Scholar 

  105. Tsao PS, Aoki N, Lefer DJ, Johnson G, Lefer AM (1990) Time course of endothelial dysfunction and myocardial injury during myocardial ischemia and reperfusion in the cat. Circulation 82: 1402–1412

    Google Scholar 

  106. Vaporciyan AA, DeLisser HM, Yan HC, Mendiguren II, Thom SR, Jones ML, Wand PA, Albelda SM (1993) Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo. Science 262: 1580–1582

    Google Scholar 

  107. Virkhaus R, Lucchesi BR, Simpson PJ, Shebuski RJ (1995) The role of adhesion molecules in cardiovascular pharmacology: Meeting review. J Pharm Exp Therap 273: 569–575

    Google Scholar 

  108. von Andrian UH, Chambers JD, McEvoy LM, Bargatze RF, Arfors KE, Butcher EC (1991) Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivo. Proc Natl Acad Sci USA 88: 7538–7542

    Google Scholar 

  109. Weyrich AS, Ma X, Lefer DJ, Albertine KH, Lefer AM (1993) In vivo neutralization of P-selectin protects feline heart and endothelium in myocardial ischemia and reperfusion injury. J Clin Invest 91: 2620–2629

    Google Scholar 

  110. Weyrich AS, McIntyre TM, McEver RP, Prescott SM, Zimmerman GA (1995) Monocyte tethering by P-selectin regulates monocyte chemotactic protein-1 and tumor necrosis factor-alpha secretion. Signal integration and NF-kappa B translocation. J Clin Invest 95: 2297–2303

    Google Scholar 

  111. Williams FM, Kus M, Tanda K, Williams TJ (1994) Effect of duration of ischemia on reduction of myocardial infarct size by inhibition of neutrophil accumulation using an anti-CD18 monoclonal antibody. Br J Pharmacol 111: 1123–1128

    Google Scholar 

  112. Winquist R, Frei P, Harrison P, McFarland M, Letts G, Van G, Andrews L, Rothlein R, Hintze T (1990) Anti-CD18 MAb limits infarct size in primates following myocardial ischemia and reperfusion. Circulation 82 (Suppl III): 701

    Google Scholar 

  113. Yamazaki T, Seko Y, Tamatami T, Miyasaka M, Yagita H, Okumura K, Nagai R, Yazaki Y (1993) Expression of intercellular adhesion molecule-1 in rat heart with ischemia/reperfusion and limitation of infarct size by treatment with antibodies against cell adhesion molecules. Am J Path 143: 410–418

    Google Scholar 

  114. Yourker KA, Hawkins HK, Kuki-- GL (1994) Molecular evidence for induction of ICAM-1 in the viable border zone associated with ischemia-reperfusion injury of the dog heart. Circulation 89: 2736–2746

    Google Scholar 

  115. Zimmerman GA, McIntyre TM, Mehra M, Prescott SM (1990) Endothelial cell-associated platelet-actiyating factor: a novel mechanism for signalling intercellular adhesion. J Cell Biol 110: 529–540

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Blood Research Institute, The Blood Center of Southeastern Wisconsin, 53213, Milwaukee, Wisconsin, USA

    R. J. Gumina, P. J. Newman & D. Kenny

  2. Department of Cellular Biology and Anatomy, Medical College of Wisconsin, 53226, Milwaukee, Wisconsin, USA

    R. J. Gumina & P. J. Newman

  3. Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, 53226, Milwaukee, Wisconsin, USA

    P. J. Newman, D. C. Warltier & G. J. Gross

  4. Department of Medicine, Division of Cardiology, Medical College of Wisconsin, 53226, Milwaukee, Wisconsin, USA

    D. Kenny & D. C. Warltier

  5. Department of Anesthesiology, Medical College of Wisconsin, 53226, Milwaukee, Wisconsin, USA

    D. C. Warltier

Authors
  1. R. J. Gumina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. J. Newman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. Kenny
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. C. Warltier
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G. J. Gross
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

R. J. Gumina is a fellow in the Medical Scientist Training Program at the Medical College of Wisconsin. This work was supported in part by a predoctoral fellowship to RJG from the American Heart Association, Wisconsin Affiliate and NIH Grants HL08311 (GJG), HL40926 (PJN), and HL54280 (DCW).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gumina, R.J., Newman, P.J., Kenny, D. et al. The leukocyte cell adhesion cascade and its role in myocardial ischemia-reperfusion injury. Basic Res Cardiol 92, 201–213 (1997). https://doi.org/10.1007/BF00788515

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00788515

Key words

Search

Navigation