Summary
This work deals with the study of the effect of antitumor serum on the dynamics of changes of mitotic activity in Ehrlich's subcutaneous adenocarcinoma, as well as in the epithelium of the cornea and crypts of the small intestine in the same experimental animals. The results of the experiment conducted on 84 male mice demonstrated that the antitumor serum has a depressing effect on the mitotic activity of Ehrlich's adenocarcinoma for a period of 4 days after the administration of the serum; the depression of cell division is more intense during the first 48 hours. There are no significant changes of mitotic activity in the corneal epithelium and crypts of the small intestine in mice with subcutaneously inoculated Ehrlich's adenocarcinoma for 5 days after the administration of the anti-tumor serum.
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V. N. Dobrokhotov, Byull. Éksptl. Biol. i Med., No. 3, 59–62 (1955).
S. V. Sukhorukikh, Immunology of Normal and Malignant Tissues, pp. 85–93. Moscow, 1956 [In Russian].
S. V. Sukhorukikh, Proceedings of a Scientific Conference on Technical Problems of the Immunology of Malignant Neoplasms, p. 26, Moscow, 1956 [in Russian].
S. V. Sukhorukikh, Byull. Éksptl. Biol. i Med., 48, No. 7, 83–86 (1959).
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Sukhorukikh, S.V. The effect of antitumor serum on the mitotic activity of neoplastic and normal tissues in the mouse. Bull Exp Biol Med 48, 1407–1410 (1959). https://doi.org/10.1007/BF00788359
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DOI: https://doi.org/10.1007/BF00788359