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The effect of salts of copper and manganese on the cholinergic systems of the heart

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Copper and manganese salts, in small concentrations (5×10−8 to 1×10−6), thus causes a decrease in the amplitude of the contractions of the isolated frog's heart; under these circumstances the systolic contractions is weakened and the diastolic relaxation is diminished. The heart rate is unaffected. This action of copper and manganese salts does not take place after preliminary atropinization of the heart. The action of copper is to cause a decrease in the reactivity of the heart to acetylcholine, connected with blocking of the sulfhydryl groups by the copper; manganese, on the contrary, increases the sensitivity of the heart to acetylcholine.

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Authors and Affiliations

  1. Department of Normal Physiology of the Stanislav Medical Institute, Stanislav, USSR

    V. S. Raitses & Ya. V. Ganitkevich

Authors
  1. V. S. Raitses
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  2. Ya. V. Ganitkevich
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Raitses, V.S., Ganitkevich, Y.V. The effect of salts of copper and manganese on the cholinergic systems of the heart. Bull Exp Biol Med 48, 1391–1395 (1959). https://doi.org/10.1007/BF00788355

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  • DOI: https://doi.org/10.1007/BF00788355

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