Bulletin of Experimental Biology and Medicine

, Volume 48, Issue 5, pp 1384–1386 | Cite as

The biological role of uranium in the mammalian body

  • D. P. Kladienko
Pathological Physiology and General Pathology


Uranium nitrate injected subcutaneously into rabbits in the dose of 0.1 mg/kg of body weight for a period of 30 days causes a considerable depression of the ability of the thyroid gland to include radioiodine administered to the animal. The gland is enlarged and the changes in the parenchyma histologically resemble those seen in goiter.

A similar histological picture was observed in rats; the latter are much less sensitive to uranium salts than rabbits. Thus, uranium nitrate (uranyl) is a natural powerful inhibitor of the thyroid gland, and may be one of its natural goiterogenic factors.


Public Health Nitrate Body Weight Uranium Uranyl 
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Literature Cited

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    N. A. Gabelova, The Use of Radioactive Isotopes in Medicine, pp. 74–78, Moscow, 1953 [In Russian].Google Scholar
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    D. P. Kladienko and R. A. Nadopta, Doklady Akad. Nauk SSSR, 115, 6, 1217–1219 (1957). Original Russian pagination. See C. B. TranslationGoogle Scholar
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    E. A. Maynard and H. S. Hodge, The Pharmacology and Toxicology of Uranium Compounds. Moscow, 1951 [Russian translation].Google Scholar
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    F. L. Haven and H. S. Hodge, The Pharmacology and Toxicology of Uranium Compounds, vol. 2, pp. 22–35. Moscow, 1951 [Russian translation].Google Scholar
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    J. Hoffmann, Biochemische Ztschr., 1943, Bd. 313, H. 5–6.Google Scholar

Copyright information

© Consultants Bureau Enterprises, Inc. 1960

Authors and Affiliations

  • D. P. Kladienko
    • 1
  1. 1.Department of Histology of the Chernovtsy Medical InstituteChernovtsyUSSR

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