Bulletin of Experimental Biology and Medicine

, Volume 48, Issue 5, pp 1380–1383 | Cite as

Changes in the ammonia and glutamine content of the brain in rats after administration of sodium bromide and caffeine and in carbon tetrachloride poisoning

  • B. G. Gordon
Pathological Physiology and General Pathology


The ammonia and glutamine content in the brain of rats is not increased by the action of caffeine and low doses of sodium bromide. Conversely, the animals' behavior and the content of ammonia and glutamine in the brain rises under the effect of large doses of sodium bromide.

Increase of the ammonia and glutamine content in the brain occurring in carbon tetrachloride poisoning does not drop noticeably under the effect of caffeine or sodium bromide. Investigations of rats' brain at different intervals after CCl4 administration (in 1–2 hours and in 24 hours) show that the increase of the ammonia and glutamine content in the brain occurs only when marked injury of the liver tissue takes place, i.e., in 24 hours, not-withstanding the fact that the general condition of rats is particularly grave in 1–2 hours. This confirms the supposition that disturbances of the central nervous system occuring in diseases of the liver may be also due to the action of ammonia.


Public Health Sodium Ammonia Nervous System Central Nervous System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. [1]
    N. V. Veselkin and B. G. Gordon, Byull. Éksptl. Biol. i Med., 47, No. 3, 34 (1959). Original Russian pagination. See C. B. Translation.Google Scholar
  2. [2]
    É. A. Gordienko, Proceedings of a Conference of Junior Scientific Workers of the Institute of Hygiene of Work and Occupational Diseases, p. 26, Moscow, 1957 [In Russian].Google Scholar
  3. [3]
    G. G. Gur'yanova, Changes in the Respiration of the Brain, Heart and Liver and in the Adenosinetriphosphate Content of the Brain during Prolonged Drug-Induced Sleep. Author's summary of dissertation, Leningrad, 1958 [In Russian].Google Scholar
  4. [4]
    K. S. Kosyakov, Farmakol. i Toksikol., No. 4, 17 (1956).Google Scholar
  5. [5]
    É. É. Martinson and L. Ya. Tyakhepyl'd, The Biochemistry of the Nervous System, p. 176. Kiev, 1957 [In Russian].Google Scholar
  6. [6]
    S. P. Bessman and A. N. Bessman, Clin. Invest., 1955, v. 34, p. 622.Google Scholar
  7. [7]
    S. P. Bessman, J. F. Fazekas and A. N. Bessman, Proc. Soc. Exper. Biol. and Med., 1954, v. 85, p. 66.Google Scholar
  8. [8]
    J. F. Fazekas, H. E. Ticktin and W. R. Ehrmantraut, et al., Am. J. Med., 1956, v. 21, p. 843.Google Scholar
  9. [9]
    T. P. Bharadwaj and P. P. Nair, Indian. J. Med. Sc., 1956, v. 10, p. 651.Google Scholar
  10. [10]
    J. Hoffman, M. B. Himes and S. Lapan et al., Arch. Path., 1955, v. 59, p. 429.Google Scholar

Copyright information

© Consultants Bureau Enterprises, Inc. 1960

Authors and Affiliations

  • B. G. Gordon
    • 1
  1. 1.Laboratory of Biochemistry of the Nervous System of the I. P. Pavlov Institute of Physiology of the AN SSSRLeningrad

Personalised recommendations