Bulletin of Experimental Biology and Medicine

, Volume 47, Issue 2, pp 216–220 | Cite as

The significance of sulfhydryl groups in the action of derivatives of quaternary ammonium bases (Re: The action mechanism of the ganglioblocking drugs)

  • M. L. Tarakhovskii
Pharmacology
  • 9 Downloads

Summary

The author studied the effect of cysteine and urea and thiol poison (cadmium chloride) on the effect of ganglioblocking substances, i.e. the derivatives of the quarternary ammonium bases. Experiments demonstrated that the action of different salts of hexamethylene bis-trimethylammonium-ganglioblocking, curare-like and depressing the work of the isolated heart-may be inhibited by the substances which change the concentration of the free SH-groups in the innervated tissues. These facts allow one to conclude that the reactivity of the sulfhydryl groups change when impulse conductivity through the ganglionic synapses is blocked.

Keywords

Public Health Chloride Ammonium Urea Cadmium 

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Copyright information

© Consultants Bureau 1959

Authors and Affiliations

  • M. L. Tarakhovskii

There are no affiliations available

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