Summary
The author studied the effect of cysteine and urea and thiol poison (cadmium chloride) on the effect of ganglioblocking substances, i.e. the derivatives of the quarternary ammonium bases. Experiments demonstrated that the action of different salts of hexamethylene bis-trimethylammonium-ganglioblocking, curare-like and depressing the work of the isolated heart-may be inhibited by the substances which change the concentration of the free SH-groups in the innervated tissues. These facts allow one to conclude that the reactivity of the sulfhydryl groups change when impulse conductivity through the ganglionic synapses is blocked.
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Department of Pharmacology of the Chernovitsi Medical Institute
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Tarakhovskii, M.L. The significance of sulfhydryl groups in the action of derivatives of quaternary ammonium bases (Re: The action mechanism of the ganglioblocking drugs). Bull Exp Biol Med 47, 216–220 (1959). https://doi.org/10.1007/BF00788157
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DOI: https://doi.org/10.1007/BF00788157