Bulletin of Experimental Biology and Medicine

, Volume 47, Issue 2, pp 187–191 | Cite as

A study of protein synthesis in damaged mitochondria

  • A. M. Zubovskaya
  • V. S. Tongur
Biochemistry and Biophysics


Experiments were performed with mitochondrias lyzed in distilled water. It was demonstrated that mitochondrias have to be intact for formation of the cofactor required for the protein biosynthesis in vitro. Isolated intact mitochondrias are able to synthesize protein without any addition of a previously obtained cofactor.

Destructed mitochondrias as are able to synthesize protein only with the addition of a cofactor obtained from intact mitochondrias. Treatment with crystalline ribonuclease results in the inhibition of the protein synthesis both by intact and destructed mitochondrias.


Public Health Protein Synthesis Protein Biosynthesis Crystalline Ribonuclease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. [1]
    A. M. Zubovskaya and V. S. Tongur, Voprosy Med. Khim. 4, 6, 439 (1958).Google Scholar
  2. [2]
    O. Lindberg and L. Ernster, Problems of Cytophysiology pp. 111–212, Moscow, (1957). In Russian.Google Scholar
  3. [3]
    R. B. Khesin and S. K. Petrashkaite, Biokhimiya 20, 5, 597–609 (1955).Google Scholar
  4. [4]
    J. L. Gamble, J. Biol. Chem. 228, 955 (1957).Google Scholar
  5. [5]
    J. L. Gamble and A. L. Lehninger, J. Biol. Chem. 223, 921 (1957).Google Scholar
  6. [6]
    T. Hultin, A. Decken and G. Beskow, Exper. Cell. Res. 12, 675 (1957).Google Scholar
  7. [7]
    P. Siekevitz, Journ. Biol. Chem. 195, 549 (1952).Google Scholar
  8. [8]
    P. Siekevitz and M. L. Watson, Biochem. Biophys. Acta 25, 274 (1957).Google Scholar
  9. [9]
    A. Ullmann and F. B. Straub, Acta physiol. Acad. Sc. hung. 11, 12 (1957).Google Scholar

Copyright information

© Consultants Bureau 1959

Authors and Affiliations

  • A. M. Zubovskaya
    • 1
  • V. S. Tongur
    • 1
  1. 1.Institute of Experimental Biology of the AMN SSSRMoscow

Personalised recommendations