The study of bacteriostatic and chemotherapeutic action of the antituberculous preparation 1314 and its chlorhydrate
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The authors conducted an experimental study of the bacteriostatic and chemotherapeutic effect of the autituberculous preparation 1314 (thiamido-α-ethylisonicotinic acid) and its hydrochloride. The preparation appeared to be nonactive with respect to gram positive and gram negative microbes in vitro. However, it possesses a high bacteriostatic activity with respect to theMycobacteriumtuberculosis including certain strains resistant to other antibiotics. The chemotherapeutic effect of the preparation was checked on white mice with experimentally induced hematogenous tuberculosis. Daily administration of the preparations per os (1–2 mg per mouse) retards the development of tuberculosis. The same results were obtained with administration of the hydrochloride of the 1314 per os and subcutaneously in the dose of 2 mg per mouse.
KeywordsPublic Health Experimental Study Tuberculosis Hydrochloride Daily Administration
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