Summary
Experiments on rats demonstrate that large doses of penicillin and streptomycin may cause changes in the content of ammonia in the brain (penicillin increases and streptomycin decreases the content). These changes are considered to be due to the effect of these antibiotics on the central nervous system (a stimulating effect of penicillin and a depressing one of streptomycin).
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Klimov, A.N. The effect of large doses of penicillin and streptomycin on the ammonia content of brain. Bull Exp Biol Med 46, 1109–1111 (1958). https://doi.org/10.1007/BF00787945
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DOI: https://doi.org/10.1007/BF00787945