Study of the sorptive properties of some organs in experimental tuberculosis, using the supravital staining method
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Inoculation of guinea pigs with virulent or attenuated cultures ofM. tuberculosis is followed by an immediate fall in the sorptive capacity for neutral red of the spleen and the lungs, to a minimum at the end of the first day, followed by a steep rise to a peak value, which coincides in time with the appearance of tubercles in histopathological preparations. The sorptive capacity fluctuations vary in amplitude parallel with the severity of the tuberculous process, in the ascending order: BCG inoculation, inoculation of immunized animals with virulent culture, inoculation of nonimmunized animals with virulent culture. The changes in sorptive capacity are a far more delicate indication of the very earliest stages of tuberculous infection than are histopathological methods.