Summary
Preparation BZ-55 caused hypoglycemia in normal rabbits, potentiated the hypoglycemic effect of insulin and inactivated insulinase of the liver. Insulinase is not found in rabbits with fatty dystrophy of the liver caused by carbon tetrachloride intoxication. The hypoglycemic effect of insulin is increased. Administration of BZ-55 (Nadizan) does not cause any hypglycemic action and does not potentiate the effect of injected insulin, although the insular pancreatic apparatus is uninjured. These experiments permit to draw a conclusion that the hypoglycemic effect of BZ-55 is connected not only with the stimulation of the β-cells but also with the activation of the peripheral action of insulin. It is mainly caused by the inactivation of hepatic insulinase.
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Leites, S.M., Smirnova, N.P. The role of liver in the mechanism of hypoglycemic action of the antidiabetic sulfanilamides. Bull Exp Biol Med 46, 1077–1080 (1958). https://doi.org/10.1007/BF00787938
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DOI: https://doi.org/10.1007/BF00787938