Bulletin of Experimental Biology and Medicine

, Volume 47, Issue 3, pp 348–351 | Cite as

The effect of a fall of the temperature on regeneration in the amphibia and on the resistance of the regenerating tissue under these conditions to the cytotaxic action of novembichin and TEM

  • E. Ch. Pukhal'skaya
Experimental Biology


The average velocity of growth of the tail regenerate inRana temporaria andR. ridibunda tadpoles of the II and III stage (according to Blacher) was studied at various temperatures. It was demonstrated that the average 24-hours temperature of 18–20°C is the optimal for the growth of the regenerate. By decreasing the water temperature by 2–4°C the velocity of the regenerate's growth is retarded by 60% (in comparison with the growth at the optimal temperature). The author studied the effect of colchicin, novembichin and 2, 4, 6 triethyleneimio 1, 3, 5-triazine (TEM)on the regeneration of the tail at optimal temperature (type A), as well as in its regeneration at decreased temperatures (type B). The technique of administration of these preparations into the tadpole body cavity was developed and LD 100% determined. The process of regeneration in type B revealed the resistance to the effect of novembichin and TEM.


Public Health Water Temperature Colchicin Average Velocity Body Cavity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. [1]
    V. Ya. Aleksandrov and N. L. Fel'dman, Bot. Zhur. 43, 2, 194–213 (1958).Google Scholar
  2. [2]
    L. F. Larionov, Patol. Fiziol. i. Eksptl. Terap. 1, 3 14–21 (1957).Google Scholar
  3. [3]
    M. I. Lyutova, Bot. Zhur. 43, 2 283–287 (1958).Google Scholar
  4. [4]
    M. N. Meisel', N. A. Pomoshchnikova and T. S. Sokolova, Doklady Akad. Nauk SSSR, 117, No. 1, 142–145 (1957). In Russian.Google Scholar
  5. [5]
    Yu. I. Polyanskii (assisted by A. F. Orlova), Zool. Zhur. 36, 11, 1630–1647 (1957).Google Scholar
  6. [6]
    L. F. Sharlikova, Voprosy Onkol. 1, 6 74–79 (1955).Google Scholar
  7. [7]
    S. Chevremont-Comhaire and M. Chevremont, Compt. rend. Soc. Bio. 150, 1046–1049 (1956).Google Scholar
  8. [8]
    J. Christophersen and H. Precht, Biol. Zbl. 72, 104–119 (1953).Google Scholar
  9. [9]
    A. Kanitz, Temperatur und Lebensvorgange, Berlin 1915.Google Scholar
  10. [10]
    M. Luscher, Rev. suisse, zool. 53, 683–734 (1946).Google Scholar
  11. [11]
    Y. X. Maruyama and T. Yanagira, J Bact. 71, 542–546 (1956).Google Scholar
  12. [12]
    Y. Miura, H. Katayama and M. Goto, Abstr. Sympos. chemother cancer Tokyo, 1957.Google Scholar
  13. [13]
    O. Sherbaum and E. Zeuthen, Exper. cell. research 6, 221–227 (1954).Google Scholar

Copyright information

© Consultants Bureau, Inc. 1959

Authors and Affiliations

  • E. Ch. Pukhal'skaya
    • 1
  1. 1.Laboratory of Chemotherapy of the Institute of Experimental Pathology and Therapy of CancerAMN SSSRMoscow

Personalised recommendations