Bulletin of Experimental Biology and Medicine

, Volume 47, Issue 3, pp 301–305 | Cite as

Mitogenetic analysis of the protein substrate of protoplasm

Part II. Dividing cells and cells which have emerged from the “Meristematous” state
  • N. S. Slavina
Biochemistry and Biophysics


It has been shown, by means of mitogenetic spectrum analysis that during the proliferative stage of cells (yeast, newt larvae, newborn guinea pigs), and in proliferating tissues of adult animals (guinea pig labial epithelium, rabbit cornea) there is relatively little interlinking of cytoplasmic peptide chains. This is shown by the relative narrowness of the spectral bands due to the functional groups R−C=O and R−C6H4OH. Where active proliferation has ceased, the peptide chains are interlinked by weak molecular bonds, giving rise to two-and three-dimensional structures.

The mitotic process thus involves profound and co-ordinated reconstruction of all cell components.


Peptide Spectrum Analysis Active Proliferation Spectral Band Adult Animal 
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Literature Cited

  1. [1]
    A. G. Gurvich and L. D. Gurvich, Mitogenetic Radiation, Its Physicochemical Bases, and Its Applications to Biology and Medicine (Moscow, 1945). In Russian.Google Scholar
  2. [2]
    A. G. Gurvich and L. D. Gurvich, Introduction to the Study of Mitogenesis (Moscow, 1948). In Russian.Google Scholar

Copyright information

© Consultants Bureau, Inc. 1959

Authors and Affiliations

  • N. S. Slavina
    • 1
  1. 1.Mitogenesis Laboratory, Institute of Normal and Pathological PhysiologyAMN SSSRMoscow

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