Summary
As shown in experiments on dogs single acute blood loss causes a rapidly appearing and considerable reduction of blood properdin. Gradual normalization of properdin level was observed in 2–5 days after blood loss. With repeated blood loss the tolerance of the properdin system developed quickly, and no properdin level drop was provoked by blood exfusions. It is suggested that the changes of the properdin system activity are one of the factors causing a lower resistance to infection in animals which sustained an acute blood loss.
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Garfunkel', M.L., Chertkov, I.L. Activity of the properdin system in acute blood loss. Bull Exp Biol Med 54, 839–842 (1963). https://doi.org/10.1007/BF00787631
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DOI: https://doi.org/10.1007/BF00787631