Summary
It was established that dimedrol averted the development of Shwartzman's phenomenon in rabbits when administered intracutaneously as follows: 1) simultaneously with the preparatcry dose of filtrate ofB. coli, 2) simultaneously with the resolving dose of filtrate ofB. coli and 3) one hour after the administration of the resolving dose of filtrate ofB. coli. Dimedrol did not avert the phenomenon in viscera.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
E. I. Arshavskaia, Biull. Eksptl. Biol. i Med. 36, 1, 19–22 (1953).
N. I. Vylegzhanin and V. I. Kashurets, Arch. Pat. No. 4, 27–33, 1949.
B. L. Mazur, Kazan Med. Zhurn. No. 3-4, 483–495, 1935.
G. Shwartzman, Phenomenon of Local Tissue Reactivity and Its Immunological, Pathological and Clinical Significance, New York, 1937.
Author information
Authors and Affiliations
Additional information
Diphenhydramine hydrochloride.
Rights and permissions
About this article
Cite this article
Rodionova, E.I. The effect of dimedrol on the development of Shwartzman's phenomenon. Bull Exp Biol Med 46, 984–985 (1958). https://doi.org/10.1007/BF00787340
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00787340