Skip to main content

Effect of nitrous oxide on “spontaneous” salivation in dogs


Inhalation of nitrous oxide-oxygen mixtures containing not less than 40% of nitrous oxide causes “spontaneous” salivation and masticatory movements in dogs. The magnitude of the response varies with the concentration of nitrous oxide, with the sensitivity to stimulation of the alimentary center, and with the previous conditioning of the animals. The effect is due mainly to strengthening of the function of the subcortical alimentary center, resulting from removal of cortical inhibition. After numerous exposures of the animals to inhalation of nitrous oxide the effects may be elicited by passing the gas through the upper respiratory passages only. This effect is mediated by natural conditioned reflex, which is elaborated by repeated exposure to the gas, and which suffers extinction with further repetition.

This is a preview of subscription content, access via your institution.

Literature Cited

  1. N. A. Podkopaev, Methods for the Study of Conditioned Reflexes (Moscow, 1952). In Russian.

  2. S. I. Potekhin, Transactions of the Russian Med. Assoc. of St. Petersburg 78, 234 (1911). In Russian.

    Google Scholar 

  3. E. Z. Pushkareva and E. A. Beliavskaia, Zhur. Eksptl. Biol. i Med. 13, No. 34, 37–42 (1930).

    Google Scholar 

  4. T. P. Rolich, Izvest. AN SSSR, No. 3, 120–128 (1950).

    Google Scholar 

  5. A. I. Smirnov, cited from T. P. Rolich.

  6. P. M. Starkov, Gas Anesthesia (Moscow, 1950). In Russian.

  7. V. K. Fedorov, Sequence of Disturbances of Higher Nervous Functions (Thesis, Leningrad, 1942).

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Aganiants, E.K. Effect of nitrous oxide on “spontaneous” salivation in dogs. Bull Exp Biol Med 46, 969–972 (1958).

Download citation

  • Received:

  • Issue Date:

  • DOI: