Summary
The author studied the changes which took place in the composition of the blood within 4 hours following the injection of 4–5 ml of 1% novocain solution to 30 rabbits. The number of leukocytes was increased in healthy animals in 2 to 4 hours.
After denervation of carotid sinuses and spleen this reaction was considerably intensified (for 2–18 months after the operation). Blood-letting acts in the same way but its effect is shorter. Changes in the number of erythrocytes and in the hemoglobin content are not consistent, but are rather pronounced. In 2/3 of all cases this response to injection of novocain was more marked than that due to injection of physiological saline. 3–4 weeks after denervation of carotid sinuses novocain injection caused an increase in the number of reticulocytes in the peripheral blood due to their egress from the bone marrow.
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Literature Cited
B. I. Baiandurov. Trophic Function of the Brain, Moscow, 1949. In Russian.
M. L. Belenkii and Iu. N. Strolkov, Biull. Eksptl. Biol. i Med. 30 No. 5 (11) 358–360 (1950).
N. N. Beller, Transactions of the Military-Naval Medical, Academy, 55, 315–316 1956.
R. A. Durinian, Biull. Eksptl. Biol. i Med. 42, No 9, 15–20 (1956). Original Russian pagination. See C. B. Translation.
E. L. Kan, Biull. Eksptl. Biol. i Med. 37 No. 3, 29–33 (1954).
S. G. Kachanova, Biull. Eksptl. Biol. i Med. 41, No. 1, 11–13 (1956). Original Russian pagination. See C. B. Translation.
K. A. Maslovskaia, Biull. Ekptl. Biol. i Med. 36, No. 4 (10) 59–63 (1953).
N. S. Rozanova and E. A. Zhukova, Problemy Gematol. 1, No. 3, 14–18 (1956).
A. M. Sarvanov, Changes in the Composition of the Blood Following Denervation of the Carotid Sinuses and Transection of Depressor Nerves, Author's abstract of Dissertation, Khabarovsk, 1956. In Russian.
A. Ia. Iaroshevskii, Biull. Eksptl. Biol. i Med. 30, No. 11, 320–324 (1950).
A. Ia. Iaroshevskii, Biull. Eksptl. Biol. i Med. No. 5, 50–53 (1958). Original Russian pagination. See C. B. Translation.
W. C. Grandt, Am. J. Physiol. 1951, v. 164, pp. 226–233.
E. Komiya, Die zentralnervöse Regulation des Blutbildes. Stuttgart, 1956.
A. L. Latner, J. Physiol. 1938, v. 93, pp. 75–80.
J. W. Linman and F. H. Bethell, Blood, 1957, v. 2, pp. 123–129.
M. Terzioglu, C. Göral and J. Baldavit, J. Am. Physiol. 1955, v. 182, N. 1, pp. 100–104.
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Iaroshevskii, A.I. The effect of intravenous novocain injections on the blood system. Bull Exp Biol Med 46, 929–933 (1958). https://doi.org/10.1007/BF00787327
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DOI: https://doi.org/10.1007/BF00787327