The effect of preliminary radioisotope administration on the peripheral blood composition and the survival of animals subsequently X-irradiated with a lethal dose
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To increase the radioresistance radioisotopes — I131, P32 and methionine-S35—were administered to rats 15, 45 and 55 days prior to the total x-irradiation. The survival of rats, to which 20 C of the isotope was previously administrated, increased by 5–23% in comparison with controls, depending on the type of isotope and the interval between the isotope administration and the subsequent x-irradiation in a dose of 800 r. The survival of the mice, to which methionine was administered 15 days prior to the x-irradiation in a dose of 600 r, increased by 38%. The number of the peripheral blood leukocytes increased after the administration of radioisotopes to rats. A relatively high lcukocyte count in experimental rats was retained after the total x-irradiation. As demonstrated, this rise was mainly due to the increased number of neutrophils and eosinophils.
KeywordsPublic Health Methionine Lethal Dose Peripheral Blood Leukocyte Blood Composition
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