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Biological activity of the polysaccharide glucan

  • Microbiology and Immunity
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Experiments on rabbits showed that glucan has the property of causing changes in the body characteristic of many bacterial polysaccharides: a reaction of the leukocytes, an increase in the phagocytic activity of the reticuloendothelial system, and an increase in the resistance of mice and chick embryos to bacterial infection. “Hydrolyzed” glucan does not possess these properties. Earlier studies [2] showed that “hydrolyzed” glucan differs in its chemical structure from the original glucan: its molecule contains no β=1∶6 bond. The associated decrease in molecular weight and change in the configuration of the molecule apparently result in the loss of biological activity of this polysaccharide.

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Literature Cited

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Authors and Affiliations

  1. Laboratory of new antibiotics, Department of Microbiology Central Postgraduate Medical Institute, Institute of Biological and Medical Chemistry of the AMN SSSR, Moscow

    G. E. Vaisberg, A. I. Braude, T. V. Golosova, V. M. Kuznetsova & M. E. Preobrazhenskaya

  2. Laboratory of Clinical Chemical and Biochemistry of Carbohydrate Metabolism, Institute of Biological and Medical Chemistry of the AMN SSSR, Moscow

    G. E. Vaisberg, A. I. Braude, T. V. Golosova, V. M. Kuznetsova & M. E. Preobrazhenskaya

Authors
  1. G. E. Vaisberg
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  2. A. I. Braude
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  3. T. V. Golosova
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  4. V. M. Kuznetsova
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  5. M. E. Preobrazhenskaya
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Additional information

Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 55, No. 6, pp. 84–87, June, 1963

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Vaisberg, G.E., Braude, A.I., Golosova, T.V. et al. Biological activity of the polysaccharide glucan. Bull Exp Biol Med 55, 667–669 (1964). https://doi.org/10.1007/BF00786812

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  • DOI: https://doi.org/10.1007/BF00786812

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