Summary
Experiments were conducted on oxen to study the conditioned-reflex mechanism responsible for maintaining the serum globulins at a high level. The results confirmed the theory that the immunological reactions of the organims are regulated by a conditioned-reflex mechanism and shed light on the physiological mechanisms of the cortical control of antibody synthesis. Apparently conditioned-reflex stimuli modify the intensity of the general nonspecific function of the immunogenetic apparatus, namely the synthesis of immune globulins, and thereby regulate the synthesis and production of specific antibodies.
Similar content being viewed by others
Literature Cited
A. P. Vishnyakov, D. S. Dobrovol'skii, N. V. Ermakov, et al., Doklady Akad. Nauk SSSR 87, 6, 1035 (1952).
A. E. Gurvich, Labor. delo,3, 3 (1955).
A. P. Dzhmukhadze, V. V. Dzheiranishvili, and A. I. Dosychev, Zh. vyssh. nervn. deyat., 4, 599 (1960).
V. I. Ioffe and L. P. Kopytovskaya, In the book: Experimental and Clinical Immunology [in Russian], Leningrad (1959), p. 175.
V. I. Luk'yanenko, Uspekhi sovr. biol. 51, 2, 170 (1961).
F. Flynn and P. de Mayo, The Lancet,2 (1951), p. 235.
W. Topley and G. Wilson, The Principles of Bacteriology and Immunity, Baltimore (1936).
J. Tsukahara, Immuni.-Forsch., Bd. 19, S. 519 (1913).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Luk'yanenko, V.I., Flerov, B.A., Megreladze, O.Y. et al. Conditioned reflex regulation of the serum globulin level. Bull Exp Biol Med 55, 664–666 (1964). https://doi.org/10.1007/BF00786811
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00786811