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N, N1-malonyl-bis-ethylenimine (MEI) and some of its biological properties

  • Pharmacology
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Bulletin of Experimental Biology and Medicine Aims and scope

Summary

The work describes the synthesis of N N1-malonyl-bis-ethylenimine (a representative of a class of chemical compounds uninvestigated as yet) by condensation of carbon suboxide with ethylenimine.

A study of biological activity of the given compound demonstrated that the latter possessed a marked cytostatic action in relation to the normal and tumor cells in the tissue cultures. The preparation is an inhibitor of various bacteriophages both resistant and sensitive to the derivatives of di-B-chlorethylamine. Besides, in comparatively high concentrations it possessed bacteriostatic and bactericidal properties in respect to Gram-positive and Gramnegative bacilli. N N1-malonyl-bis-ethylenimine presents a definite interest for further study of its antitumor properties.

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Authors and Affiliations

  1. Department of Microbiology of the Leningrad Sanitation-Hygiene Medical Institute, Leningrad, USSR

    L. B. Borisov, V. G. Beilin, L. B. Dashkevich & G. S. Yakovleva

  2. Department of Organic Chemistry of the Leningrad Chemico-Pharmaceutical Institute, Leningrad, USSR

    L. B. Borisov, V. G. Beilin, L. B. Dashkevich & G. S. Yakovleva

Authors
  1. L. B. Borisov
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  2. V. G. Beilin
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  3. L. B. Dashkevich
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  4. G. S. Yakovleva
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Borisov, L.B., Beilin, V.G., Dashkevich, L.B. et al. N, N1-malonyl-bis-ethylenimine (MEI) and some of its biological properties. Bull Exp Biol Med 55, 660–663 (1964). https://doi.org/10.1007/BF00786810

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  • DOI: https://doi.org/10.1007/BF00786810

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