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Effects of brief and prolonged stimulation of the hypothalamus on the free and combined cholesterol contents of blood

  • Biochemistry and Biophysics
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Threshold-strength stimulation of the hypothalamus of white rats, under conditions of chronic experimentation, affected the blood cholesterol level differently, depending on the duration of the course of stimulations. The initial effect was to raise blood cholesterol, but after prolonged stimulation (1–1.5 months), the cholesterol content fell, following application of the stimulus, to below the initial level; the greatest changes were in the free cholesterol content. The same type of response was given by different hypothalamic structures. The part played by the hypothalamus in regulation of cholesterol metabolism is discussed.

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Authors and Affiliations

  1. Experimental Department, Rostov-on-Don Scientific-Research Institute of Roentgenology. Radiology, and Oncology, Ministry of Health, RSFSR, Rostov-on-Don, USSR

    Yu. N. Bordyushkov & L. Kh. Garkavi

Authors
  1. Yu. N. Bordyushkov
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  2. L. Kh. Garkavi
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Bordyushkov, Y.N., Garkavi, L.K. Effects of brief and prolonged stimulation of the hypothalamus on the free and combined cholesterol contents of blood. Bull Exp Biol Med 55, 645–648 (1964). https://doi.org/10.1007/BF00786806

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  • DOI: https://doi.org/10.1007/BF00786806

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