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The significance of overexcitation of the central nervous system in the genesis of experimental hypertensive stroke

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Experiments were conducted on 74 albino rats, highly sensitive to the bell (37 with renal hypertension and 37-control). In the development of experimental hypertensive stroke of great significance are: the initial excitation of the CNS (particularly of the structures determining the data of motor reaction); intensity of ischemization of both kidneys (the extent of the renal tissue ischemization), the initial blood pressure level (which coincides with Steshenko's observations-8). The role of the initial factor in the development of experimental hypertensive stroke may be played by the functional overexcitation of the CNS; fatal cerebral strokes occur in such cases in 27 percent of the animals. The latter circumstance indicates that a functional model of experimental hypertensive stroke has been created.

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Literature Cited

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Authors and Affiliations

  1. Laboratory of Pathophysiology of Higher Nervous Activity of the Department of Physiology of Higher Nervous Activity of the M. V. Lomonosov Moscow State University, Moscow, USSR

    L. V. Krushinskii, A. Kh. Kogan, L. P. Dobrokhotova & N. P. Modenova

  2. Department of Pathophysiology of the I. M. Sechenov I Moscow Order of Lenin Medical Institute, Moscow, USSR

    L. V. Krushinskii, A. Kh. Kogan, L. P. Dobrokhotova & N. P. Modenova

Authors
  1. L. V. Krushinskii
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  2. A. Kh. Kogan
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  3. L. P. Dobrokhotova
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  4. N. P. Modenova
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Krushinskii, L.V., Kogan, A.K., Dobrokhotova, L.P. et al. The significance of overexcitation of the central nervous system in the genesis of experimental hypertensive stroke. Bull Exp Biol Med 55, 624–626 (1964). https://doi.org/10.1007/BF00786800

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  • DOI: https://doi.org/10.1007/BF00786800

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