Summary
Mice (not pure bred) were painted three times with 1% O-aminoazotoluene in benzene. On the fourth day after the last painting, partial hepatectomy was performed. The mice were killed 30, 36, 48, 54, 60, 72, and 78 hours after the operation. O-aminoazotoluene inhibited the mitotic activity of liver cells in the hepatectomized mice, but no inhibition was observed in the control mice painted with benzene, or with the noncarcinogenic diethylaminoazobenzene.
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Candidate of Medical Sciences V. I. Gel'shtein took part in the scientific direction of the work.
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Kuans-Hua, H. The influence of the carcinogen orthoaminoazotoluene on the reactivity of liver cells after partial hepatectomy. Bull Exp Biol Med 53, 592–594 (1963). https://doi.org/10.1007/BF00786753
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DOI: https://doi.org/10.1007/BF00786753