Summary
Serum antigens were studied in 23 fetuses by precipitation in agar. There were fewer serum antigens in the human embryo than in the adult. The difference was in direct proportion to fetal age, and was due on the one hand to the absence in fetus of the antigens known to be present in the adult, and on the other to the increase in the number of fetal antigens during development, by differentiation of the serum antigens already present.
It was shown that during the intrauterine period, antigens were present in the human blood serum which were absent from the blood serum of adults. These antigens are also found in the serum of the frog and fish. This observation shows that the “Law of Recapitulation” applies also to the human blood serum antigens.
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Tsoneva-Maneva, M. Intrauterine development of the isoantigens of human serum. Bull Exp Biol Med 53, 569–572 (1963). https://doi.org/10.1007/BF00786747
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DOI: https://doi.org/10.1007/BF00786747