Summary
In experiments in vitro, large doses of plague toxin depressed the activity of diamineoxidase (DO) of the lungs of albino rats. The action was relatively specific, as could be judged by the absence of any significant effect on it of toxins of Brucella, cholera vibrio, or the pseudotuberculosis bacterium. The effect of a small dose of theP. pestis toxin on the DO of rat lungs was quite insignificant (P>0.05). The DO of the horse and sheep sera was more sensitive toP. pestis, but the action was less specific. From experiments in vivo on rats which were investigated 4–48 hours after receiving an intraperitoneal injection of 1 LD50 of plague toxin showed that no definite changes in the activity of the DO of the lungs was caused (P>0.05).
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Domaradskii, I.V., Klimova, I.M. The influence of plague toxin on diamineoxidase. Bull Exp Biol Med 53, 549–551 (1963). https://doi.org/10.1007/BF00786742
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DOI: https://doi.org/10.1007/BF00786742