Stimulation of nonspecific immunity by some bacterial polysaccharides
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A substance with polysaccharide component was isolated fromAcxylinum, which was called ciine. This substance sharply increases the resistance of white mice to sepsis caused by staphylococcus,E. coli,Pr. vulgaris andB. pyocyaneum. The action of ciine is connected with the participation of a number of body protective systems. Experiments demonstrated the activation of the local peritoneum apparatus, stimulation of the phagocytic activity of the reticulo-endothelial system as a whole and a rise of the blood bactericidal activity. Comparison of the effect produced by ciine with the action of certain other substances of the polysaccharides has made it possible to divide all the substances tested into 2 groups. Ciine, zymosan and polysaccharide obtained from the K-12E. coli, belonged to one group whereas agar, pyrogenal, polyglycine, grysean-to another one. Substances of the first group provoke a protective effect if administered 12 to 96 hours prior to infection of the mice. The protective action of the substances belonging to the second group is weaker, inconstant and is manifested only when administered 12 to 24 hours prior to infection.
KeywordsPublic Health Agar Polysaccharide Protective Effect Bactericidal Activity
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- 1.A. I. Brande, et al., Antibiotiki, No. 3, p. 23 (1959).Google Scholar
- 2.Z. V. Ermol'eva, et al., Antibiotiki, No. 6, p. 46 (1958).Google Scholar
- 3.Z. V. Ermol'eva, et al., Antibiotiki, No. 4, p. 37 (1960).Google Scholar
- 4.E. Kass, Bact. Rev.24, (1960) p. 177.Google Scholar
- 5.M. Landy and L. Pillemer, J. exp. Med.104, (1956), p. 383.Google Scholar
- 6.L. Pillemer, et al., Science,120, (1954), p. 279.Google Scholar
- 7.D. Rowley, Brit. J. exp. Path.,37, (1956), p. 223.Google Scholar