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Blood insulin level in rats after injury to the ventromedial hypothalamus

  • R. S. Gol'dberg
  • Yu. N. Kasatkin
  • Ya. A. Lazaris
  • L. K. Smirnova
Pathological Physiology and General Pathology
  • 16 Downloads

Abstract

Experiments on rats showed that injury to the ventromedial portion of the hypothalamus or interruption of its nervous connections is followed by hyperinsulinemia; in conjunction with the hyperphagia, this could be the direct cause of the adiposity.

Key Words

adiposity hypothalamus insulin 

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Literature Cited

  1. 1.
    S. M. Leites, Adiposity. General Pathology [in Russian], Moscow (1948).Google Scholar
  2. 2.
    S. M. Leites, in: Textbook of Pathological Physiology in Several Volumes [in Russian], Vol. 2, Moscow (1966), p. 312.Google Scholar
  3. 3.
    S. M. Leites and N. N. Lapteva, Outlines of the Pathophysiology of Metabolism and the Endocrine System [in Russian], Moscow (1967), p. 99.Google Scholar
  4. 4.
    L. L. Bernardis and L. A. Frohman, J. Comp. Neurol.,141, 107 (1971).Google Scholar
  5. 5.
    E. L. Bierman, J. D. Bogdade, and D. Porte, Am. J. Clin. Nutr.,21, 1434 (1968).Google Scholar
  6. 6.
    V. Bleisch, J. Mayer, and M. Dicke, Am. J. Path.,28, 368 (1952).Google Scholar
  7. 7.
    J. D. Bogdade, Lancet,2, 630 (1968).Google Scholar
  8. 8.
    G. Freytag, Acta Histochem. (Jena), Suppl. 10, 451 (1971).Google Scholar
  9. 9.
    L. A. Frohman and L. L. Bernardis, Endocrinology,82, 1125 (1968).Google Scholar
  10. 10.
    J. De Groot, J. Comp. Neurol.,113, 389 (1959).Google Scholar
  11. 11.
    C. N. Hales and R. L. Randle, Biochem. J.,88, 137 (1963).Google Scholar
  12. 12.
    C. N. Hales and G. C. Kennedy, Biochem. J.90, 620 (1964).Google Scholar
  13. 13.
    B. E. Hustvedt and A. Lovo, Acta Physiol. Scand.,84, 29 (1972).Google Scholar
  14. 14.
    J. H. Karam, G. M. Grodsky, and P. H. Forsham, Am. J. Clin. Nutr.,21, 1445 (1968).Google Scholar
  15. 15.
    W. J. Malaisse, F. Malaisse-Lagae, and D. L. Coleman, Metabolism,17, 802 (1968).Google Scholar
  16. 16.
    E. Pfeiffer, Proc. Roy. Soc. Med.,62, 355 (1969).Google Scholar
  17. 17.
    A. B. Steffens, Physiol. Behav.,5, 107 (1970).Google Scholar

Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • R. S. Gol'dberg
    • 1
    • 2
  • Yu. N. Kasatkin
    • 1
    • 2
  • Ya. A. Lazaris
    • 1
    • 2
  • L. K. Smirnova
    • 1
    • 2
  1. 1.Department of Pathological PhysiologyKaraganda Medical InstituteUSSR
  2. 2.Department of Medical RadiologyCentral Postgraduate Medical InstituteMoscow

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