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Distribution of nucleic acids in the cell nuclei of normal liver and transplanted mouse hepatoma

  • Biochemistry and Biophysics
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

It was shown that desoxyribonucleic acid (DNA) constituted 10–14% of dry substance of cellular nuclei in normal liver and about 3–4% of the nuclei of mice hepatoma. Practically all DNA (90–98%) is found in nucleoprotein fraction in both cases. Ribonucleic acid (RNA) constitutes 0.4–1.4% of dry substance of the cellular nuclei in normal liver as well as in transplanted hepatoma in mice. However, the ratio of RNA to DNA in the nuclei of hepatoma is greater than normal. Nuclear RNA is found both in the nucleoprotein fraction and in acid protein. Its quantity evidently depends to a great extent on the admixture of cytoplasm. No nucleic acids are found in the residual protein.

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Literature Cited

  1. S. S. Debov, Biokhimiia, 16, No. 4, 314–320 (1951).

    Google Scholar 

  2. I. B. Zbarskii and S. S. Debov, Doklady Akad. Nauk SSSR, 62, No. 6, 795–798 (1948).

    Google Scholar 

  3. I. B. Zbarskii and S. S. Debov, Biokhimiia, 16, No. 5, 390–395 (1951).

    Google Scholar 

  4. I. B. Zbarskii and K. A. Perevoshchikova, Biokhimiia, 16, No. 5, 392–124 (1951).

    Google Scholar 

  5. A. L. Dounce, In the book: Modern Problems of Cytology, Russian translation. Moscow, 1955, pp. 51–71.

  6. A. W. Pollister, In the book: Modern Problems of Cytology, Russian translation. Moscow, 1955, pp. 91–111.

  7. A. L. Dounce, Journ. Biol. Chem. 1943, Vol. 147, No. 3, pp. 685–698.

    Google Scholar 

  8. A. L. Dounce, The Nucleic Acids, 1955, Vol. 2, p. 97.

    Google Scholar 

  9. Ch. Fiske and I. Subbarow, J. Biol. Chem. 1925, Vol. 66, pp. 375–400.

    Google Scholar 

  10. H. W. Kosterlitz, J. Physiol., 1947, Vol. 106, No. 2, pp. 194–210.

    Google Scholar 

  11. A. E. Mirsky and A. W. Pollister, J. Gen. Physiol., 1946, Vol. 30, No. 2, pp. 117–147.

    Google Scholar 

  12. G. Schmidt and S. I. Thannhauser, J. Biol. Chem., 1945, Vol. 161, No. 1, pp. 83–89.

    Google Scholar 

  13. I. M. Webb and H. B. Levy. J. Biol. Chem., 1955, Vol. 213, No. 1, pp. 107–117.

    Google Scholar 

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Authors and Affiliations

  1. Biochemical Laboratory, The P. A. Gertsen State Oncologic Institute, Moscow

    S. M. Saidov

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  1. S. M. Saidov
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Saidov, S.M. Distribution of nucleic acids in the cell nuclei of normal liver and transplanted mouse hepatoma. Bull Exp Biol Med 45, 45–47 (1958). https://doi.org/10.1007/BF00785973

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  • DOI: https://doi.org/10.1007/BF00785973

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