Skip to main content
SpringerLink
Log in

Control of K+ channels by G proteins

  • Mini-Review
  • Published:
Journal of Bioenergetics and Biomembranes Aims and scope Submit manuscript

Abstract

Heterotrimeic G proteins are thought to couple receptors to ionic channels via cytoplasmic mediators such as cGMP in the case of retinal rods, cAMP in the case of olfactory cells, and the cAMP cascade in the case of cardiac myocytes. G protein-mediated second messenger effects on K+ channels are dealt with elsewhere in this series. Recently, membrane-delimited pathways have been uncovered and an hypothesis proposed in which the α subunits of G proteins directly couple receptors to ionic channels, particularly K+ channels. While direct coupling has not been proven, the membrane-delimited nature has been established for specific G proteins and their specific K+ channel effectors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Aghajanian, G. K., and Wang, Y.-Y. (1986).Brain Res. 371, 390–394.

    Google Scholar 

  • Andrade, R., Malenka, R., and Nicoll, R. A. (1986).Science 234, 1261–1265.

    Google Scholar 

  • Bourne, H. R. (1989).Nature (London)337, 504–505.

    Google Scholar 

  • Breitwieser, G. E., and Szabo, G. (1985).Nature (London)317, 538–540.

    Google Scholar 

  • Brown, J. H., and Brown, S. L. (1984).J. Biol. Chem. 259, 3777–3781.

    Google Scholar 

  • Cerbai, E., Klöckner, U., and Isenberg, G. (1988).Science 240, 1782–1783.

    Google Scholar 

  • Codina, J., Grenet, D., Yatani, A., Birnbaumer, L., and Brown, A. M. (1987a).FEBS Lett. 216, 104–106.

    Google Scholar 

  • Codina, J., Yatani, A., Grenet, D., Brown, A. M., and Birnbaumer, L. (1987b).Science 236, 442–445.

    Google Scholar 

  • Deretic, D., and Hamm, H. E. (1987).J. Biol. Chem. 262, 10839–10847.

    Google Scholar 

  • Endoh, M., Manyama, M., and Tajima, T. (1985).Am. J. Physiol. 249, H309-H320.

    Google Scholar 

  • Gähwiler, B. H., and Brown, D. A. (1985).Proc. Natl. Acad. Sci. USA 82, 1558–1562.

    Google Scholar 

  • Glitsch, H. G., and Pott, L. (1978).J. Physiol. (London)279, 655–668.

    Google Scholar 

  • Halvorsen, S. W., and Nathanson, N. M. (1984).Biochemistry 23, 5813–5821.

    Google Scholar 

  • Hamm, H. E., Deretic, D., Hofmann, K. P., Schleicher, A., and Kohl, B. (1988).J. Biol. Chem. 262, 10831–10838.

    Google Scholar 

  • Hartzell, H. (1980).J. Cell Biol. 86, 6–20.

    Google Scholar 

  • Hazeki, O., and Ui, M. (1981).J. Biol. Chem. 256, 2856–2862.

    Google Scholar 

  • Hohl, C. M., and Rosen, R. (1987).Biochem. Biophys. Acta 921, 356–363.

    Google Scholar 

  • Jelsema, C. L., and Axelrod, J. (1987).Proc. Natl. Acad. Sci. USA 84, 3623–3627.

    Google Scholar 

  • Katada, T., Bokoch, G. M., Northup, J. K., Ui, M., and Gilman, A. G. (1984a).J. Biol. Chem. 259, 3568–3577.

    Google Scholar 

  • Katada, T., Bokoch, G. M., Smigel, M. D., Ui, M., and Gilman, A. G. (1984b).J. Biol. Chem. 259, 3586–3595.

    Google Scholar 

  • Kim, D., Lewis, D. L., Graziadei, L., Neer, E. J., Bar-Sagi, D., and Clapham, D. E. (1989).Nature (London)337, 557–560.

    Google Scholar 

  • Kirsch, G. E., and Brown, A. M. (1989).Am. J. Physiol. 257, H334–338.

    Google Scholar 

  • Kirsch, G. E., Yatani, A., Codina, J., Birnbaumer, L., and Brown, A. M. (1988).Am. J. Physiol. 23, H1200–1205.

    Google Scholar 

  • Kurachi, Y., Nakajima, T., and Sugimoto, T. (1986a).Pflügers Arch. 407, 264–274.

    Google Scholar 

  • Kurachi, Y., Nakajima, T., and Sugimoto, T. (1986b).Am. J. Physiol. 251, H681–684.

    Google Scholar 

  • Kurachi, Y., Ito, H., Sugimoto, T., Shimizu, T., Miki, I., and Ui, M. (1989).Nature (London)337, 555–557.

    Google Scholar 

  • Kurose, H., and Ui, M. (1983).J. Cyclic Nucleotide Protein Phosphorylation Res. 9, 305–318.

    Google Scholar 

  • Logothetis, D. E., Kurachi, Y., Galper, J., Neer, E. J., and Clapham, D. E. (1987).Nature (London)325, 321–326.

    Google Scholar 

  • Logothetis, D. E., Kim, D., Northup, J. K., Neer, E. J., and Clapham, D. E. (1988).Proc. Natl. Acad. Sci. USA 85, 5814–5818.

    Google Scholar 

  • Mattera, R., Yatani, A., Kirsch, G. E., Graf, R., Olate, J., Codina, J., Brown, A. M., and Birnbaumer, L. (1989).J. Biol. Chem. 264, 465–471.

    Google Scholar 

  • Mihara, S., North, R. A., and Surprenant, A. (1987).J. Physiol. 390, 335–355.

    Google Scholar 

  • Moore, S. D., Madamba, S. G., Joels, M., and Siggins, G. R. (1988).Science 239, 278–280.

    Google Scholar 

  • Nargeot, J., Nerbonne, J. M., Engels, J., and Lester, H. A. (1983).Proc. Natl. Acad. Sci. USA 80, 2395–2399.

    Google Scholar 

  • Nawrath, H. (1977).Nature (London)267, 72–74.

    Google Scholar 

  • North, R. A., and Williams, J. T. (1985).J. Physio. (London)364, 265–280.

    Google Scholar 

  • North, R. A., Williams, J. T., Surprenant, A., and Christie, M. J. (1983).Proc. Natl. Acad. Sci. USA 84, 5487–5491.

    Google Scholar 

  • Northup, J. K., Smigel, M. D., Sternweis, P. C., and Gilman, A. G. (1983).J. Biol. Chem. 258, 11369–11376.

    Google Scholar 

  • Osterrieder, W., Yang, Q.-F., and Trautwein, W. (1982). InCardiac Rate and Rhythm (Bouman, L. N., and Jongsma, H. T., eds.), Martinus Nijhoff, Boston, pp. 485–505.

    Google Scholar 

  • Parent, L., and Coronado, R. (1989).J. Gen. Physiol. 94(3, 445–463.

    Google Scholar 

  • Pfaffinger, P. J., Martin, J. M., Hunter, D. D., Nathanson, N. M., and Hille, B. (1985).Nature (London)317, 536–538.

    Google Scholar 

  • Pind, S., and Kuksis, A. (1988).Biochem. Biophys. Acta 938, 211–221.

    Google Scholar 

  • Purves, R. V. (1976).Nature (London)261, 159–151.

    Google Scholar 

  • Ribalet, B., Ciani, S., and Eddlestone, G. T. (1989).J. Gen. Physiol. 94, 693–717.

    Google Scholar 

  • Rosenberger, L. B., Roeske, W. R., and Yamamura, H. I. (1979).Eur. J. Pharmacol. 56, 179–180.

    Google Scholar 

  • Sasaki, K., and Sato, M. (1987).Nature (London)325, 259–262.

    Google Scholar 

  • Schlegel, W., Wuarin, F., Zbaren, C., Wolheim, C. B., and Zahnd, G. R. (1985).FEBS Lett. 189, 27–32.

    Google Scholar 

  • Sirota, S., Tsuji, Y., and Pappano, A. (1985).Fed. Proc. 44, 729 (abstract).

    Google Scholar 

  • Soejima, M., and Noma, A. (1984).Pflügers Arch. 400, 424–431.

    Google Scholar 

  • Tajima, T., Tsuji, Y., Brown, J. H., and Pappano, A. J. (1987).Circ. Res. 61, 436–445.

    Google Scholar 

  • Trautwein, W., Taniguchi, J., and Noma, A. (1982).Pflügers Arch. 392, 307–314.

    Google Scholar 

  • Trussell, L. O., and Jackson, M. B. (1987).J. Neurosci. 7, 3306–3316.

    Google Scholar 

  • VanDongen, A., Codina, J., Olate, J., Mattera, R., Joho, R., Birnbaumer, L., and Brown, A. M. (1988).Science 242, 1433–1437.

    Google Scholar 

  • Yakel, J. L., Trussell, L. O., and Jackson, M. B. (1988).J. Neurosci. 8(4, 1273–1285.

    Google Scholar 

  • Yamashita, N., Shibuya, N., and Ogata, E. (1986).Proc. Natl. Acad. Sci. USA 83, 6198–6202.

    Google Scholar 

  • Yatani, A., Codina, J., Brown, A. M., and Birnbaumer, L. (1987a).Science 235, 207–211.

    Google Scholar 

  • Yatani, A., Codina, J., Sekura, R. D., Birnbaumer, L., and Brown, A. M. (1987b).Mol. Endocrinol. 1, 283–289.

    Google Scholar 

  • Yatani, A., Hamm, H. E., Codina, J., Mazzoni, M. R., Birnbaumer, L., and Brown, A. M. (1988a).Science 241, 828–831.

    Google Scholar 

  • Yatani, A., Mattera, R., Codina, J., Graf, R., Okabe, K., Padrell, E., Iyengar, R., Brown, A. M., and Birnbaumer, L. (1988b).Nature (London)336, 680–682.

    Google Scholar 

  • Yatani, A., Okabe, K., Birnbaumer, L., and Brown, A. M. (1990).Am. J. Physiol. 258, H1507–1514.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, 77030, Houston, Texas

    Arthur M. Brown, Atsuko Yatani, Glenn Kirsch, Kouji Okabe, Antonius M. J. VanDongen & Lutz Birnbaumer

  2. Department of Cell Biology, Baylor College of Medicine, One Baylor Plaza, 77030, Houston, Texas

    Lutz Birnbaumer

Authors
  1. Arthur M. Brown
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Atsuko Yatani
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Glenn Kirsch
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kouji Okabe
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Antonius M. J. VanDongen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Lutz Birnbaumer
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brown, A.M., Yatani, A., Kirsch, G. et al. Control of K+ channels by G proteins. J Bioenerg Biomembr 23, 499–507 (1991). https://doi.org/10.1007/BF00785808

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00785808

Key Words

Search

Navigation