Summary
The vitamins thiamine and nicotinic acid were studied in the tissues of children dying from dysentery alone, dysentery complicated by pneumonia and various acute surgical conditions. Specific subdivisions of the brain as well as some internal organs were examined. The age range was 0 to 2 years.
Nicotinic acid was not found to be diminished seriously, if at all. Thiamine underwent marked depletion, particularly in the central nervous system. This is in agreement with experimental data obtained on studies performed with growing puppies.
There is substanial reason for the belief that thiamine depletion plays a role in the pathogenesis of dysentery.
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Zaprudskaya, D.S. Thiamine and nicotinic acid content of various subdivisions of the brains of children dying of certain infectious diseases. Bull Exp Biol Med 43, 602–605 (1957). https://doi.org/10.1007/BF00785746
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DOI: https://doi.org/10.1007/BF00785746