Summary
Reflexes obtained by perfusion of isolated intestinal loops with Shiga exotoxin and nicotine were used. Normal animals were tested first. Then, cats received large doses of Shiga dysenteric exotoxin subcutaneously and the isolated loop technique was followed within 4–6 hours in some animals; one, two and four days in others. Various concentrations of nicotine were used. Dysentery toxin was also placed on the mucosa of the loop as a definite maneuver.
The results were somewhat conflicting but there seemed to be an alteration of the reflexes in response to the stimuli. The time interval from the toxin injection is of great importance. Originally, there seems to be reenforcement of the reflexes; this being followed, later, by an inhibition.
The healthy animals were unaffected. These alterations are of such a nature that patients, already Ill with dysentery, may have clinical manifestations analogous to those described here experimentally. It is doubtful if dysentery toxins play any role in the etiology of the disease.
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Myagkhaya, I.P. The mechanism of dysenteric intoxication. Bull Exp Biol Med 43, 597–601 (1957). https://doi.org/10.1007/BF00785745
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DOI: https://doi.org/10.1007/BF00785745