Abstract
The effect of a method of assisted circulation (counterpulsation) on the ultrastructure of the myocardium was studied in dogs. Electron microscopy revealed a sharp increase in the glycogen content in the heart muscle cells, mitochondria with a highly osmophilic, finely granular matrix, and high pinocytotic activity of the capillary endothelial cells. The results are evidence of metabolic changes in the myocardium and, in particular, that the myocardial muscle cells are functioning at a lower energy level. The changes discovered in the myocardial ultrastructure evidently account for the beneficial therapeutic effect of the method.
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Shumakov, V.I., Tolpekin, V.E. & Kleimenova, N.N. Effect of the assisted circulation on myocardial ultrastructure. Bull Exp Biol Med 82, 1871–1874 (1976). https://doi.org/10.1007/BF00785723
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DOI: https://doi.org/10.1007/BF00785723